Title:Alterations of the Gut Microbiome and Metabolome Following: A Opportunity for Early Detection of Colorectal Cancer
Volume: 21
Issue: 1
Author(s): Mehdi Pezeshgi Modarres, Mohammad Amin Habibi, Mohammad Reza Pashaei, Yousef Mohammadpour, Kimia Jazi and Sajjad Ahmadpour*
Affiliation:
- Patient Safety Research Center,
Clinical Research Institute, Urmia University of Medical Sciences, Urmia, Iran
Keywords:
Colorectal cancer, diagnosis, microbiota, gut, metabolite, screening.
Abstract: Colorectal cancer (CRC) is a commonly diagnosed cancer responsible for numerous deaths
worldwide. In recent decades, technological advances implicated in considering the molecular pathways
underlying CRC pathogenesis. Several investigations have identified various mechanisms involved
in CRC and have paved the way for new therapeutics and early diagnosis. Gut microbiome
play a crucial role in intestinal inflammation and can be associated with colitis colorectal cancer. In
this review, we narrated the role of the microbiome population and their metabolome profile as a new
screening method for early detection of CRC.
