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Current Topics in Medicinal Chemistry

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ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

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Review Article

The Neurobiology of Formal Thought Disorder

Author(s): Erik Dornelles* and Diogo Telles Correia

Volume 24, Issue 20, 2024

Published on: 18 January, 2024

Page: [1773 - 1783] Pages: 11

DOI: 10.2174/0115680266272521240108102354

Price: $65

Abstract

The concept of Formal Thought Disorder (FTD) is an ambiguous and disputed one, even though it has endured as a core psychopathological construct in clinical Psychiatry. FTD can be summarized as a multidimensional construct, reflecting difficulties or idiosyncrasies in thinking, language, and communication in general and is usually subdivided into positive versus negative. In this article, we aim to explore the putative neurobiology of FTD, ranging from changes in neurotransmitter systems to alterations in the functional anatomy of the brain. We also discuss recent critiques of the operationalist view of FTD and how they might fit in its biological underpinnings. We conclude that FTD might be the observable phenotype of many distinct underlying alterations in different proportions.

Keywords: Formal thought disorder, Neurobiology, Psychopathology, Neurotransmitters, Neuroglia, Multidimensional construct.

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