Title:An Update to Novel Therapeutic Options for Combating Tuberculosis:
Challenges and Future Prospectives
Volume: 25
Issue: 14
Author(s): Swathi Suresh, Rukaiah Fatma Begum, Ankul Singh S.*Chitra Vellapandian*
Affiliation:
- Department of Pharmacology, SRM College of Pharmacy, SRMIST, Kattankulathur, 603 203, Tamil Nadu, India
- Department of Pharmacology, SRM College of Pharmacy, SRMIST, Kattankulathur, 603 203, Tamil Nadu, India
Keywords:
Tuberculosis, pretomanid, host directed therapy, repurposed drugs, DOTS, bedaquiline.
Abstract: Drug repurposing is an ongoing and clever strategy that is being developed to eradicate
tuberculosis amid challenges, of which one of the major challenges is the resistance developed
towards antibiotics used in standard directly observed treatment, short-course regimen.
Surpassing the challenges in developing anti-tuberculous drugs, some novel host-directed therapies,
repurposed drugs, and drugs with novel targets are being studied, and few are being approved
too. After almost 4 decades since the approval of rifampicin as a potent drug for drugsusceptible
tuberculosis, the first drug to be approved for drug-resistant tuberculosis is bedaquiline.
Ever since the urge to drug discovery has been at a brisk as this milestone in tuberculosis
treatment has provoked the hunt for novel targets in tuberculosis. Host-directed therapy and repurposed
drugs are in trend as their pharmacological and toxicological properties have already
been researched for some other diseases making the trial facile. This review discusses the remonstrance
faced by researchers in developing a drug candidate with a novel target, the furtherance
in tuberculosis research, novel anti-tuberculosis agents approved so far, and candidates on
trial including the host-directed therapy, repurposed drug and drug combinations that may prove
to be potential in treating tuberculosis soon, aiming to augment the awareness in this context to
the imminent researchers.