Mannose: A Promising Player in Clinical and Biomedical Applications

Title:Mannose: A Promising Player in Clinical and Biomedical Applications

Volume: 21 Issue: 11

Author(s): Sijing Chen, Kana Wang and Qiao Wang*

Affiliation:

• Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan, China
• The Department of Gynecologic Oncology, West China Second Hospital, Sichuan University, Chengdu, Sichuan, China

Keywords: Mannose, anti-infective therapy, immune system, antitumor effects, drug carriers, wound healing.

Abstract: Mannose, an isomer of glucose, exhibits a distinct molecular structure with the same formula but a different atom arrangement, contributing to its specific biological functions. Widely distributed in body fluids and tissues, particularly in the nervous system, skin, testes, and retinas, mannose plays a crucial role as a direct precursor for glycoprotein synthesis. Glycoproteins, essential for immune regulation and glycosylation processes, underscore the significance of mannose in these physiological activities. The clinical and biomedical applications of mannose are diverse, encompassing its anti-inflammatory properties, potential to inhibit bacterial infections, role in metabolism regulation, and suggested involvement in alleviating diabetes and obesity. Additionally, mannose shows promise in antitumor effects, immune modulation, and the construction of drug carriers, indicating a broad spectrum of therapeutic potential. The article aims to present a comprehensive review of mannose, focusing on its molecular structure, metabolic pathways, and clinical and biomedical applications, and also to emphasize its status as a promising therapeutic agent.

Cite this article as:

Chen Sijing, Wang Kana and Wang Qiao*, Mannose: A Promising Player in Clinical and Biomedical Applications, Current Drug Delivery 2024; 21 (11) . https://dx.doi.org/10.2174/0115672018275954231220101637