Title:Mannose: A Promising Player in Clinical and Biomedical Applications
Volume: 21
Issue: 11
Author(s): Sijing Chen, Kana Wang and Qiao Wang*
Affiliation:
- Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of
Education, Chengdu, Sichuan, China
- The Department of Gynecologic Oncology, West China Second Hospital,
Sichuan University, Chengdu, Sichuan, China
Keywords:
Mannose, anti-infective therapy, immune system, antitumor effects, drug carriers, wound healing.
Abstract: Mannose, an isomer of glucose, exhibits a distinct molecular structure with the same formula
but a different atom arrangement, contributing to its specific biological functions. Widely distributed
in body fluids and tissues, particularly in the nervous system, skin, testes, and retinas, mannose
plays a crucial role as a direct precursor for glycoprotein synthesis. Glycoproteins, essential for
immune regulation and glycosylation processes, underscore the significance of mannose in these
physiological activities. The clinical and biomedical applications of mannose are diverse, encompassing
its anti-inflammatory properties, potential to inhibit bacterial infections, role in metabolism regulation,
and suggested involvement in alleviating diabetes and obesity. Additionally, mannose shows
promise in antitumor effects, immune modulation, and the construction of drug carriers, indicating a
broad spectrum of therapeutic potential. The article aims to present a comprehensive review of mannose,
focusing on its molecular structure, metabolic pathways, and clinical and biomedical applications,
and also to emphasize its status as a promising therapeutic agent.