Title:A Review of the Synthesis of Oxazoline Derivatives
Volume: 22
Issue: 2
Author(s): Cynthia Nathalia Pereira, Amanda Cristina Cruz Eschholz and Maurício Silva dos Santos*
Affiliation:
- Laboratório de Síntese de Sistemas Heterocíclicos (LaSSH), Institute of Physics and Chemistry, Federal University of
Itajubá, 1303 BPS Avenue, Itajubá - MG, Brazil
Keywords:
Oxazolines, organic synthesis, solvent-free synthesis, microwave irradiation, ultrasound irradiation, chemoselectivity.
Abstract: Oxazolines are important heterocyclic systems due to their biological activities, such
as antibacterial, antimalarial, anticancer, antiviral, anti-inflammatory, antifungal, antipyretic,
and antileishmanial. They have been widely applied as chiral auxiliaries, polymers, catalysts,
protecting groups, building blocks, and ligands in asymmetric synthesis. Due to their importance,
many synthetic routes to prepare oxazoline moieties have been investigated and developed
by researchers around the world. In this review, we summarized several synthetic
methodologies published in the literature. The main substrates are nitriles, carboxylic acids,
and acid derivatives, which react with a variety of reactants under conventional heating, microwave
irradiation or ultrasound irradiation conditions. Syntheses via intramolecular cyclisation
from amides have also been reported. Many publications have highlighted procedures based on
solvent-free conditions using eco-friendly, reusable, and easy-availability catalysts.
