Title:Targeting Epigenetic Modifiers: Promising Strategies for Cancer Therapy and Beyond
Volume: 20
Issue: 1
Author(s): Dilip Kumar Chanchal*, Prateek Porwal and Nidhi Mittal
Affiliation:
- Department of Pharmacy, Smt. Vidyawati College of Pharmacy, Jhansi, Uttar Pradesh, India
Keywords:
Epigenetic modifiers, cancer therapy, DNA methylation, histone modifications, non-coding RNAs, targeted therapy.
Abstract: Epigenetic changes are important for controlling how genes are expressed and how cells
work, and their misregulation has been linked to many diseases, including cancer. Targeting epigenetic
modifiers has become a promising way to treat cancer, and it may also be useful outside of
oncology. This review article goes into detail about the rapidly changing field of epigenetic-based
therapies, with a focus on how they are used to treat cancer. We discuss in-depth the main epigenetic
changes seen in cancer, such as DNA methylation, changes to histones, and dysregulation of noncoding
RNA, as well as their roles in tumour growth, metastasis, and drug resistance. Epigenetic
drugs and small molecule inhibitors that target epigenetic enzymes and reader proteins have shown a
lot of promise in both preclinical and clinical studies on different types of cancer. We show the most
recent evidence that these epigenetic therapies work and look into how they might be used in combination
with other treatments. We talk about new research into the therapeutic potential of epigenetic
modifiers in diseases other than cancer, such as neurological disorders, autoimmune diseases, and
heart conditions. Even though there is a lot of potential for therapy, there are still problems, such as
side effects and differences between patients. We talk about the work that is still being done to get
around these problems and explain new ways to deliver epigenetic-based interventions that are more
precise and effective. For epigenetic-based therapies to be used in clinical settings, it is important to
understand how they work and how they interact with other types of treatment. As the field moves
forward, we try to figure out where it is going and what it means to target epigenetic modifiers in
cancer therapy and other areas of disease. This review looks at the role of epigenetic modulation in
shaping the landscape of precision medicine and its possible effects on human health from a broad
and forward-looking point of view.
