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Current Organic Chemistry

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ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

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Review Article

Harnessing the Pyrazine Moiety for Potent Anti-inflammatory Activity: A Comprehensive Review

Author(s): Kuldeep Singh*, Jeetendra Kumar Gupta, Kamal Shah, Sunam Saha, Marianesan Arockia Babu, Shivendra Kumar and Mohit Agrawal

Volume 28, Issue 3, 2024

Published on: 12 January, 2024

Page: [176 - 184] Pages: 9

DOI: 10.2174/0113852728279887240109110636

Price: $65

Abstract

Inflammation is an intricate physiological reaction that has a vital function in the body's protection against detrimental stimuli. Nevertheless, uncontrolled inflammation may result in the development of long-term conditions, such as arthritis, cardiovascular disorders, and even cancer. Scientists are always searching for new medicinal substances that might efficiently regulate the inflammatory response. Due to its distinctive structure and an extensive array of chemical interactions, the pyrazine moiety has emerged as a viable foundational component for synthesising anti-inflammatory drugs. This review article examines the many methods used to use the potential of pyrazine moiety for its anti-inflammatory capabilities. The paper focuses on the latest progress in the development, creation, and assessment of pyrazine-based compounds, demonstrating their modes of action and links between their structure and activity. This review aims to provide a complete overview of the current knowledge on pyrazine-derived compounds with anti-inflammatory action by gathering and critically analysing the latest research results. Moreover, the essay explores the difficulties and possibilities in this area, which sets the stage for the logical development of advanced anti-inflammatory substances using the pyrazine pattern.

Keywords: Pyrazine moiety, anti-inflammatory, inflammation, therapeutic agents, structure-activity relationships, mechanism of action, drug design.

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