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当代肿瘤药物靶点

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ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

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Review Article

肿瘤免疫微环境在胆管癌的发展中起关键作用

卷 24, 期 7, 2024

发表于: 11 January, 2024

页: [681 - 700] 页: 20

弟呕挨: 10.2174/0115680096267791231115101107

价格: $65

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摘要

胆管癌(CCA)是一种以胆管细胞分化为特征的上皮性肿瘤，也是一种纤维增生性肿瘤。其特点是间质致密，肿瘤免疫微环境(TME)复杂。TME包括细胞和非细胞成分。细胞成分包括CCA细胞、免疫细胞和以癌症相关成纤维细胞(CAFs)为代表的间充质细胞，而非细胞成分则由细胞外基质(ECM)等间充质成分代表。最近的研究表明，TME在CCA的发生、进展和治疗耐药性中起着重要作用。这些细胞相关的预后标记物以及细胞间连接可能作为潜在的治疗靶点，并可能在未来激发新的治疗方法。本文旨在总结目前对CCA免疫微环境的认识，重点是免疫细胞、间充质细胞、ECM、细胞间相互作用和微环境内的代谢。

关键词: 胆管癌，肿瘤免疫微环境，免疫细胞，间充质细胞，预后标志物，代谢。

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