Title:The Regulatory Mechanism of Hypoxia-inducible Factor 1 and its Clinical
Significance
Volume: 17
Author(s): Chun-Li Yin and Yu-Jie Ma*
Affiliation:
- Air Force Clinical College of Anhui Medical University, The Fifth Clinical College of Anhui Medical University, Hefei 230032, China
- Department of Critical Care Medicine, PLA Air Force Medical Center, Beijing 100142, China
Keywords:
Hypoxia, Hypoxia-inducible factor 1, Hypoxia-inducible factor pathway, Isoforms, Diseases, Amino acid.
Abstract: Hypoxia-inducible factor (HIF) is a nuclear protein that plays a crucial role in oxygen homeostasis through its transcriptional activity and
thousands of target gene profiles. Through transcriptional and post-transcriptional regulation, the downstream target genes of HIF can trigger
multiple pathological responses in the body, including energy metabolism, cytopenia, and angiogenesis. There are three distinct subtypes of HIF:
HIF-1, HIF-2, and HIF-3. HIF-1 is a significant regulator of the cellular response to hypoxia, and the balance between its production and
degradation is critical for this response. As hypoxia is linked to several disorders, understanding HIF can open up novel avenues for the treatment
of many diseases. This review describes the regulatory mechanisms of HIF-1 synthesis and degradation and the clinical significance of the
hypoxia-inducible factor pathway in lung injury, kidney disease, hematologic disorders, and inflammation-related diseases.
