Title:Novel Products as Promising Therapeutic Agents for Angiogenesis
Inhibition
Volume: 21
Author(s): Shaheen Sultana*, Shahnaz Sultana, Shehla Nasar Mir Najib Ullah and Ameeduzzafar Zafar
Affiliation:
- IMT College of Pharmacy, Uttar Pradesh 201310, India
Keywords:
Angiogenesis, antiangiogenic agents, cancer, carcinogenesis, phytochemicals, Novel angiogenesis inhibitors
Abstract: Objective: Angiogenesis is the process of forming new blood vessels from pre-existing
vessels and occurs during development, wound healing, and tumor growth. In this review, we aimed
to present a comprehensive view of various factors contributing to angiogenesis during carcinogenesis. Anti-angiogenesis agents prevent or slow down cancer growth by interrupting the nutrients and
blood supply to the tumor cells, and thus can prove beneficial for treatment.
Method: The discovery of several novel angiogenic inhibitors has helped to reduce both morbidity
and mortality from several life-threatening diseases, such as carcinomas. There is an urgent need for
a new comprehensive treatment strategy combining novel anti-angiogenic agents for the control of
cancer. The article contains details of various angiogenic inhibitors that have been adopted by scientists to formulate and optimize such systems in order to make them suitable for cancer.
Results: The results of several researches have been summarized in the article and all of the data
support the claim that anti-angiogenic agent is beneficial for cancer treatment.
Conclusion: This review focuses on novel antiangiogenic agents that play a crucial role in controlling carcinogenesis.
