Title:Toll-like Receptor 4 Signaling Mediates Gastritis and Gastric
Cancer
Volume: 24
Author(s): Zepeng Zhang, Ju Liu, Yi Wang, Lei Zhang, Tong Zhou, Yu Huang and Tongtong Zhu*
Affiliation:
- Department of
pharmacy, Kunshan Hospital of Integrated Traditional Chinese and Western Medicine, Suzhou, China
Keywords:
TLR4, Stomach, Helicobacter pylori, Gastric cancer, Inflammation, Signaling
Abstract: The stomach is a crucial digestive organ in the human body, highly
susceptible to inflammation or pathogen invasion, which can lead to various gastric
diseases, including gastric cancer. Toll-like receptors (TLRs) are the first line of
defense against pathogen invasion. TLR4, a member of the TLRs family, recognizes
pathogen and danger-related molecular patterns to induce inflammatory responses.
Helicobacter pylori (H. pylori) is a significant factor in gastric health, and TLR4
recognizes H. pylori -LPS to trigger an inflammatory response. Downstream TLR4
signaling generates proinflammatory cytokines that initiate inflammation in the gastric
mucosa. In addition, TLR4 gene polymorphisms can increase health risks. This study
aims to investigate the contribution of TLR4 to the inflammatory response in gastric
diseases and the relation between TLR4 and H. pylori, TLR4 gene polymorphisms,
and how TLR4 affects gastric diseases’ possible pathways to provide further insight for
future prevention and clinical treatment strategies.
