Title:Overcoming Solubility Challenges: Self-emulsifying Systems for Enhancing the Delivery of Poorly Water-Soluble Antiviral Drugs
Volume: 13
Issue: 1
Author(s): Devesh U. Kapoor, Deepak Sharma, Mansi Gaur, Bhupendra G. Prajapati*, Sontaya Limmatvapirat and Pornsak Sriamornsak*
Affiliation:
- Shree S. K. Patel College of Pharmaceutical Education and Research, Ganpat University, Kherva,
384012, India
- Department of Industrial Pharmacy, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom,
73000, Thailand
- Academy of Science, The Royal Society of Thailand, Bangkok, 10300, Thailand
- Faculty of
Pharmaceutical Sciences, Chulalongkorn University, Bangkok, 10330, Thailand
Keywords:
Self-emulsifying drug delivery systems, cosurfactant, quality target product profile, pharmacokinetics, biopharmaceutical classification system, antiviral drug.
Abstract: The primary goal of drug formulation is to improve a drug’s bioavailability in the body.
However, poorly water-soluble drugs present challenging issues related to their solubility and bioavailability
factors. Emerging technologies, such as lipid-based drug delivery systems, including micro-
or nanoemulsifying drug delivery systems, have become increasingly relevant to address the
above challenges. This review presents a thorough overview of self-emulsifying drug delivery systems
(SEDDS). It covers the properties, principles, self-emulsification mechanism, formulation strategies,
and characterization methods of SEDDS. This review also addresses the delivery of antiviral
agents through SEDDS. Moreover, it summarizes the marketed formulations of SEDDS consisting of
antiviral agents. This review offers a comprehensive and valuable resource for future perspectives on
SEDDS and their potential applications in antiviral drug delivery.
