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Current Stem Cell Research & Therapy

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ISSN (Print): 1574-888X
ISSN (Online): 2212-3946

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Review Article

Mechanisms of Stem Cells and Their Secreted Exosomes in the Treatment of Autoimmune Diseases

Author(s): Shu-Qian Lin, Kai Wang, Xing-Hua Pan and Guang-Ping Ruan*

Volume 19, Issue 11, 2024

Published on: 05 January, 2024

Page: [1415 - 1428] Pages: 14

DOI: 10.2174/011574888X271344231129053003

Price: $65

Abstract

Stem cells play a therapeutic role in many diseases by virtue of their strong self-renewal and differentiation abilities, especially in the treatment of autoimmune diseases. At present, the mechanism of the stem cell treatment of autoimmune diseases mainly relies on their immune regulation ability, regulating the number and function of auxiliary cells, anti-inflammatory factors and proinflammatory factors in patients to reduce inflammation. On the other hand, the stem cell- derived secretory body has weak immunogenicity and low molecular weight, can target the site of injury, and can extend the length of its active time in the patient after combining it with the composite material. Therefore, the role of secretory bodies in the stem cell treatment of autoimmune diseases is increasingly important.

Keywords: Hematopoietic stem cells, mesenchymal stem cells, diabetes, systemic lupus erythematosus, inflammatory bowel disease, therapy, exosome.

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Graphical Abstract

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