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Current Pharmaceutical Design

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ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

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Mini-Review Article

Role of Amphotericin B in the Treatment of Mucormycosis

Author(s): Alisha Sachdeva, Monika Targhotra, Meenakshi Kanwar Chauhan* and Monica Chopra

Volume 30, Issue 1, 2024

Published on: 04 January, 2024

Page: [1 - 9] Pages: 9

DOI: 10.2174/0113816128272443231221101415

Price: $65

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Abstract

Background: Regardless of the most recent inclusion of mold-active agents (isavuconazole and posaconazole) to antifungal agents against mucormycosis, in conjunction with amphotericin B (AMB) items, numerous uncertainties still exist regarding the treatment of this rare infection. The order Mucorales contains a variety of fungi that cause the serious but uncommon fungal illness known as mucormycosis. The moulds are prevalent in nature and typically do not pose significant risks to people. Immunocompromised people are affected by it.

Objective: This article's primary goal is to highlight the integral role that AMB plays in this condition.

Methods : Like sinusitis (including pansinusitis, rhino-orbital, or rhino-cerebral sinusitis) is one of the many signs and symptoms of mucormycosis. The National Center for Biotechnology Information (NCBI) produces a variety of online information resources for review articles on the topic-based mucormycosis, AMB, diagnosis of mucormycosis and the PubMed® database of citations and abstracts published in life science journals. These resources can be accessed through the NCBI home page at https://www.ncbi.nlm.nih.gov.

Results: The article provides a summary of the pharmacological attributes of the various AMB compositions accessible for systemic use.

Conclusion: The article demonstrates the traits of the drug associated with its chemical, pharmacokinetics, stability, and other features, and illustrates their most useful characteristics for clinical application.

Keywords: Mucormycosis, lipid formulation, amphotericin B (AMB), fungal infection, antifungal agents, sinusitis.

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