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Current Organic Synthesis

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ISSN (Online): 1875-6271

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Mini-Review Article

Recent Progress in Free Radical Transformations of Allenamides

Author(s): Yongchun Liu*, Zimin Wang, Rui Li, Yinhai Yao, Zhichuan Shi, Qin Sun and Guowei Deng*

Volume 21, Issue 7, 2024

Published on: 03 January, 2024

Page: [889 - 902] Pages: 14

DOI: 10.2174/0115701794269961231027054854

Price: $65

Abstract

Allenamides are special allenes, and the unique reactivity, selectivity (both stereoselective and regionally selective) and stability of allenamides have been widely studied. In this review, the development of the free radical transformation of allenamides over the last few years will be summarized. This review discusses in detail in three parts: intermolecular radical addition to C- X (X = N, S, O, Se) bonds, metal salt mediated cyclization of allenamides, and photocatalytic cyclization of allenamides. In addition, reasonable details of the mechanisms are provided for the vast majority of these transformations.

Keywords: Allenamides, free radical, cyclization, photocatalysis, allenes, metal catalysis.

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Graphical Abstract

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