Title:Clinical, Radiological, and Microbiologic Characteristics of Patients with Noncystic
Fibrosis Bronchiectasis in a Tertiary Center at Jordan
Volume: 20
Author(s): Asma S. Albtoosh*, Tala Altarawneh, Ahmad A. Toubasi, Mariam Malek, Dalia Mohammad Albulbol, Sulaiman F. Alnugaimshi, Amro Altarawneh, Raghad H. Alsurkhi, Khaled Al Oweidat, Randa I. Farah, Nathir Obeidat and Eman Salameh Salem Albtoush
Affiliation:
- Department of Internal Medicine, Respiratory and Sleep Medicine, School of Medicine, The University of Jordan, Amman, Jordan
Keywords:
Epidemiology, Bronchiectasis, Microbiology, Treatment, Patients, Non-Cystic fibrosis.
Abstract:
Background:
Only a small number of the investigations that were carried out in the Middle East attempted to characterize patients with NCFB. In order to
characterize patients with NCFB, as well as their etiologies, microbiological profiles, and outcomes, we therefore carried out this investigation.
Methods:
This retrospective cohort study was carried out at the Jordan University Hospital (JUH), a tertiary facility located in Amman, Jordan. Non-cystic
Fibrosis Bronchiectasis (NCFB) was defined as an HRCT scan typical for bronchiectasis along with a negative sweat chloride test to rule out cystic
fibrosis. Patients’ data were collected by the use of Electronic Medical Records (EMR) at our institution. Frequent exacerbation was defined as
more than 2 exacerbations in 1 year of the onset of the diagnosis.
Results:
A total of 79 patients were included, and 54.4% of them were female. The mean and standard deviation of the patient's age was 48.61 ± 19.62. The
etiologies of bronchiectasis were evident in 79.7% of the sample. Asthma, Chronic Obstructive Pulmonary Diseases (COPD), and Kartagener
syndrome were the most prevalent etiologies, accounting for related illnesses in 21.8%, 21.5%, and 13.9% of the patients, respectively. The most
frequent bacteria cultured in our cohort were Pseudomonas and Candida Species. Moreover, 43 patients of the study cohort were frequent
exacerbators, and 5 patients died.
Conclusion:
Our study supports the need to identify several bronchiectasis phenotypes linked to various causes. These findings provide information to clinicians
for the early detection and treatment of bronchiectasis in Jordan.
