Title:An Insight into Different Experimental Models used for Hepatoprotective
Studies: A Review
Volume: 21
Issue: 4
Author(s): Sucharita Babu, Santosh K Ranajit, Gurudutta Pattnaik, Goutam Ghosh, Goutam Rath and Biswakanth Kar*
Affiliation:
- School of Pharmaceutical Sciences, Siksha O Anusandhan Deemed to be University, Bhubaneswar, 751030,
India
Keywords:
Hepatotoxicity, animal models, toxicants, in vivo, in vitro study, liver disease, blood serum.
Abstract: Numerous factors, including exposure to harmful substances, drinking too much alcohol,
contracting certain hepatitis serotypes, and using specific medicines, contribute to the development of
liver illnesses. Lipid peroxidation and other forms of oxidative stress are the main mechanisms by which
hepatotoxic substances harm liver cells. Pathological changes in the liver include a rise in the levels of
blood serum, a decrease in antioxidant enzymes, as well as the formation of free radical radicals. It is
necessary to find pharmaceutical alternatives to treat liver diseases to increase their efficacy and decrease
their toxicity. For the development of new therapeutic medications, a greater knowledge of primary
mechanisms is required. In order to mimic human liver diseases, animal models are developed.
Animal models have been used for several decades to study the pathogenesis of liver disorders and
related toxicities. For many years, animal models have been utilized to investigate the pathophysiology
of liver illness and associated toxicity. The animal models are created to imitate human hepatic disorders.
This review enlisted numerous hepatic damage in vitro and in vivo models using various toxicants,
their probable biochemical pathways and numerous metabolic pathways via oxidative stressors, different
serum biomarkers enzymes are discussed, which will help to identify the most accurate and suitable
model to test any plant preparations to check and evaluate their hepatoprotective properties.
