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Current Organic Chemistry

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ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

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Research Article

Efficient Synthesis and Characterization of 6-substituted-N-p-tolyl-imidazo[1,2- a]pyridine-8-carboxamide: A Promising Scaffold for Drug Development

Author(s): Keval Bhatt, Dhara Patel*, Mrudangsinh Rathod, Ashish Patel and Drashti Shah

Volume 27, Issue 22, 2023

Published on: 21 December, 2023

Page: [1978 - 1984] Pages: 7

DOI: 10.2174/0113852728269243231206044929

Price: $65

Abstract

Imidazo[1,2-a]pyridine is a highly significant fused bicyclic heterocycle widely utilized in medicinal chemistry, and it holds a prominent position as a "drug prejudice" framework because of its extensive applications. Numerous approaches have been documented for the synthesis of imidazo[1,2-a]pyridines, with a particular focus on functionalizing these compounds. In this research, we have presented an effective multi-step synthesis method for producing imidazo[1,2-a]pyridines, achieving impressive yields ranging from 93% to 97%. The synthesized compounds were subjected to thorough characterization using various spectral analysis techniques, including FTIR, 1H NMR, 13C NMR, mass spectrometry, and elemental analysis. Overall, this synthetic strategy possesses desirable features for the synthesis of imidazo[1,2-a]pyridines and their derivatives, including high product purity, accessible starting materials, broad substrate scope, scalability, and transformability. These characteristics make it a promising approach for further development and potential application in the synthesis of valuable therapeutic compounds.

Keywords: Imidazo[1, 2-a]pyridine, heterocycle, drug development, medicinal chemistry, drug prejudice, NMR.

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