Title:Efficient Synthesis and Characterization of 6-substituted-N-p-tolyl-imidazo[1,2-
a]pyridine-8-carboxamide: A Promising Scaffold for Drug Development
Volume: 27
Issue: 22
Author(s): Keval Bhatt, Dhara Patel*, Mrudangsinh Rathod, Ashish Patel and Drashti Shah
Affiliation:
- Department of Chemistry, Sankalchand Patel University, Visnagar, Gujarat, India
Keywords:
Imidazo[1, 2-a]pyridine, heterocycle, drug development, medicinal chemistry, drug prejudice, NMR.
Abstract: Imidazo[1,2-a]pyridine is a highly significant fused bicyclic heterocycle widely
utilized in medicinal chemistry, and it holds a prominent position as a "drug prejudice"
framework because of its extensive applications. Numerous approaches have been documented
for the synthesis of imidazo[1,2-a]pyridines, with a particular focus on functionalizing
these compounds. In this research, we have presented an effective multi-step synthesis method
for producing imidazo[1,2-a]pyridines, achieving impressive yields ranging from 93% to
97%. The synthesized compounds were subjected to thorough characterization using various
spectral analysis techniques, including FTIR, 1H NMR, 13C NMR, mass spectrometry, and
elemental analysis. Overall, this synthetic strategy possesses desirable features for the synthesis
of imidazo[1,2-a]pyridines and their derivatives, including high product purity, accessible
starting materials, broad substrate scope, scalability, and transformability. These characteristics make it a promising
approach for further development and potential application in the synthesis of valuable therapeutic compounds.
