Login Register Cart 0
Generic placeholder image

Cardiovascular & Hematological Agents in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1871-5257
ISSN (Online): 1875-6182

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Research Article

Study of the Antihypertensive Effect of Scorzonera undulata ssp. deliciosa in Albino Wistar Rats

Author(s): Ayoub Amssayef, Mohammed Ajebli and Mohamed Eddouks*

Volume 22, Issue 2, 2024

Published on: 11 December, 2023

Page: [159 - 167] Pages: 9

DOI: 10.2174/0118715257243190231024164358

Price: $65

conference banner
Abstract

Aims: The study aimed to investigate the antihypertensive activity of Scorzonera undulata ssp. deliciosa.

Background: Scorzonera undulata ssp deliciosa, locally known as “Guiz”, is used in traditional medicine in Morocco as a diuretic and mainly against snake bites.

Objectives: This study investigated the possible antihypertensive effect of the aqueous extract of Scorzonera undulata (AESU).

Materials and Methods: In the present study, the antihypertensive activity of AESU was tested in normotensive and hypertensive rats

Results: The results indicated that AESU decreased the systolic, diastolic, and mean arterial blood pressure in hypertensive rats. The data revealed that AESU exerted its antihypertensive effect through vasodilatory properties. Interestingly, the study demonstrated that the vasorelaxation ability of AESU might be mediated through receptor-operated calcium channels (ROCCs). However, AESU dhad effect on inhibiting ACE-2.

Conclusion: The present study indicates the antihypertensive and vasorelaxant activities of AESU in hypertensive rats.

Keywords: Hypertension, Scorzonera undulata, vasodilation, aortic ring, medicinal plant, receptor-operated calcium channels, ACE-2.

« Previous Next »
Graphical Abstract

[1]
Angeli, F.; Reboldi, G.; Trapasso, M.; Gentile, G.; Pinzagli, M.G.; Aita, A.; Verdecchia, P. European and US guidelines for arterial hypertension: similarities and differences. Eur. J. Intern. Med., 2019, 63, 3-8.
[http://dx.doi.org/10.1016/j.ejim.2019.01.016] [PMID: 30732939]
[2]
Singh, P.; Mishra, A.; Singh, P.; Goswami, S.; Singh, A.; Tiwari, K.D. Hypertension and herbal plant for its treatment: A review. Indian J Res Pharm Biotechnol., 2015, 3(5), 358-366.
[3]
Maione, F.; Cicala, C.; Musciacco, G.; De Feo, V.; Amat, A.G.; Ialenti, A.; Mascolo, N. Phenols, alkaloids and terpenes from medicinal plants with antihypertensive and vasorelaxant activities. A review of natural products as leads to potential therapeutic agents. Nat. Prod. Commun., 2013, 8(4), 1934578X1300800.
[http://dx.doi.org/10.1177/1934578X1300800434] [PMID: 23738474]
[4]
Barkaoui, M.; Katiri, A.; Boubaker, H.; Msanda, F. Ethnobotanical survey of medicinal plants used in the traditional treatment of diabetes in Chtouka Ait Baha and Tiznit (Western Anti-Atlas), Morocco. J. Ethnopharmacol., 2017, 198, 338-350.
[http://dx.doi.org/10.1016/j.jep.2017.01.023] [PMID: 28109915]
[5]
Rebbas, K.; Bounar, R.; Gharzouli, R.; Ramdani, M.; Djellouli, Y.; Alatou, D. Plantes d’intérêt médicinale et écologique dans la région d’Ouanougha (M’sila, Algérie). Phytotherapie, 2012, 10(2), 131-142.
[http://dx.doi.org/10.1007/s10298-012-0701-6]
[6]
Brahim, H.; Salah, A.; Bayet, C.; Laouer, H.; Dijoux-Franca, M.G. Evaluation of antioxidant activity, free radical scavenging and cuprac of two compounds isolated from Scorzonera undulate ssp. deliciosa. Adv. Environ. Biol., 2013, 7, 591-594.
[7]
Boussaada, O.; Saidana, D.; Chriaa, J.; Chraif, I.; Ammar,; Mahjoub, M.A.; Mighri, Z.; Daami, M.; Helal, A.N.; Ammar; Mahjoub, M.A.; Mighri, Z.; Daami, M.; Helal, A.N. Chemical composition and antimicrobial activity of volatile components of Scorzonera undulata. J. Essent. Oil Res., 2008, 20(4), 358-362.
[http://dx.doi.org/10.1080/10412905.2008.9700030]
[8]
Ajebli, M.; Amssayef, A.; Eddouks, M. Antihyperglycemic Activity and Safety Assessment of the Aqueous Extract of Aerial Parts of Scorzonera undulata ssp deliciosa in Rat. Cardiovasc. Hematol. Disord. Drug Targets, 2021, 20(4), 305-316.
[http://dx.doi.org/10.2174/1871529X20666200827113029] [PMID: 32860366]
[9]
Ajebli, M.; Amssayef, A.; Eddouks, M. Assessment of Antihyperglycemic Effect and Acute Toxicity of the Aqueous Scorzonera undulata Extract in Rats. Endocr. Metab. Immune Disord. Drug Targets, 2021, 21(6), 1130-1141.
[http://dx.doi.org/10.2174/1871530320666200729151133] [PMID: 32727339]
[10]
Ajebli, M.; Eddouks, M. Eucalyptus globulus possesses antihypertensive activity in L-NAME-induced hypertensive rats and relaxes isolated rat thoracic aorta through the nitric oxide pathway. Nat. Prod. Res., 2019, 10, 1-3.
[PMID: 30966776]
[11]
Kim, B.; Jo, C.; Choi, H.Y.; Lee, K. Prunetin Relaxed Isolated Rat Aortic Rings by Blocking Calcium Channels. Molecules, 2018, 23(9), 2372.
[http://dx.doi.org/10.3390/molecules23092372] [PMID: 30227625]
[12]
Dabaghian, F.; Khanavi, M.; Zarshenas, M.M. Bioactive compounds with possible inhibitory activity of Angiotensin-Converting Enzyme-II; a gate to manage and prevent COVID-19. Med. Hypotheses, 2020, 143, 109841.
[http://dx.doi.org/10.1016/j.mehy.2020.109841] [PMID: 32425303]
[13]
Zheng, Y.Y.; Ma, Y.T.; Zhang, J.Y.; Xie, X. COVID-19 and the cardiovascular system. Nat. Rev. Cardiol., 2020, 17(5), 259-260.
[http://dx.doi.org/10.1038/s41569-020-0360-5] [PMID: 32139904]
[14]
De Maria, M.L.; Araújo, L.D.; Fraga-Silva, R.A.; Pereira, L.A.; Ribeiro, H.J.; Menezes, G.B.; Shenoy, V.; Raizada, M.K.; Ferreira, A.J. Anti-hypertensive Effects of Diminazene Aceturate: An Angiotensin- Converting Enzyme 2 Activator in Rats. Protein Pept. Lett., 2016, 23(1), 9-16.
[http://dx.doi.org/10.2174/0929866522666151013130550] [PMID: 26458404]
[15]
Sartório, C.L.; Pimentel, E.B.; dos Santos, R.L.; Rouver, W.N.; Mill, J.G. Acute hypotensive effect of diminazene aceturate in spontaneously hypertensive rats: role of NO and Mas receptor. Clin. Exp. Pharmacol. Physiol., 2020, 47(10), 1723-1730.
[http://dx.doi.org/10.1111/1440-1681.13368] [PMID: 32603499]

Rights & Permissions Print Cite
Article Metrics
18
4
Wayfinder Image
© 2024 Bentham Science Publishers | Privacy Policy