Abstract
Cancer remains a significant global health concern, and natural compounds found in fruits and vegetables have shown potential anti-cancer effects. Grapefruit (Citrus paradisi) has gained attention due to its rich phytochemical composition and biological activities, including anti-cancer properties. This narrative review analyzes the literature on grapefruit-based drug development and its potential as an adjunctive or alternative therapeutic strategy for cancer treatment. Grapefruit-derived compounds have been extensively studied for their anti-cancer effects, with preclinical studies showing promising outcomes in inhibiting cancer cell growth and proliferation. Compounds made from grapefruit also have anti-cancer effects. They do this in a number of ways, such as by affecting the cell cycle, apoptosis, angiogenesis, metastasis, and key signalling pathways. Petrified grapefruit compounds have potential synergistic effects with conventional chemotherapy drugs, enhancing cytotoxic effects while reducing adverse side effects. They have shown promising results in overcoming drug resistance, a major obstacle in cancer treatment. However, challenges such as bioavailability, drug interactions, and variability in compound composition remain. Overall, grapefruit-derived compounds possess significant anti-cancer properties and warrant further investigation for clinical application.
Keywords: Grapefruit, Citrus paradisi, anti-cancer effects, drug development, phytochemicals, natural compounds, preclinical studies, mechanism of action, synergistic effects, drug resistance, therapeutic strategy.
Call for Papers in Thematic Issues
Nutraceutical Compounds from Waste Bioresources
This thematic issue explores the potential of converting waste bioresources into valuable nutraceutical compounds. The issue will cover advanced extraction techniques, including supercritical-fluid extraction, pressurized-liquid extraction, and microwave-assisted extraction, which offer efficient methods for recovering valuable compounds like secondary metabolites, minerals, vitamins, and phytochemicals from these waste materials. The focus ...read more
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The scope of this thematic issue is to explore the rapidly expanding field of plant-based nutraceuticals, with an emphasis on sustainably sourced botanical ingredients. We kindly invite the submission of review articles, as well as original research and commentaries, that investigate the potentials of various plant-based nutraceuticals in promoting health ...read more
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