Title:Microwave-assisted Synthesis of Bioactive Six-membered O-heterocycles
Volume: 10
Issue: 2
Author(s): Aramita De, Subhankar Sarkar and Adinath Majee*
Affiliation:
- Department of Chemistry, Visva-Bharati (A Central University), Santiniketan, 731235, India
Keywords:
Microwave, O-heterocycles, bioactive, six-membered, biochemical processes, organic chemistry, chemical reactions.
Abstract: Microwave radiation has been utilised since the late 1970s as an alternative
thermal energy source for chemical reactions. Initially used in inorganic chemistry, its
potential for organic chemistry was revealed in 1986. Convertion of electromagnetic
energy into heat, with frequencies ranging from 0.3-300 GHz using microwave irradiation,
is an efficient heating method. The microwave heating method has significant
potential for industrial processes, reducing reaction times and enhancing yields and selectivity.
It finds applications in peptide and organic synthesis, materials science, polymer
chemistry, biochemical processes, and nanotechnology. Microwave-assisted organic
synthesis is environmentally friendly and beneficial for producing bioactive heterocyclic
compounds. Oxygen-containing heterocycles are abundant and possess various
biological functions, making them essential for developing new drugs. Microwave
technology facilitates the synthesis of these compounds, including bioactive six-membered
o-heterocycles such as pyrones, oxazolones, furanones, oxetanes, oxazolidinones,
and dioxetanes. By utilizing modern organic transformations, microwave-assisted
chemistry enhances the efficiency of synthetic processes, leading to the discovery
of more beneficial molecules. The review provides an up-to-date analysis of the synthesis
and medicinal properties of O-heterocycles, emphasizing the strengths and needs
of this field. It guides researchers, facilitating microwave-assisted green synthesis reactions
and offering a flexible platform for forming bioactive heterocyclic rings.
