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Review Article

Hypoxia A Typical Target in Human Lung Cancer Therapy

Author(s): Asmat Ullah*, Somia Shehzadi, Najeeb Ullah, Touseef Nawaz, Haroon Iqbal and Tariq Aziz*

Volume 25, Issue 5, 2024

Published on: 29 November, 2023

Page: [376 - 385] Pages: 10

DOI: 10.2174/0113892037252820231114045234

Price: $65

Abstract

Lung cancer (LC) is the leading cause of cancer-related death globally. Comprehensive knowledge of the cellular and molecular etiology of LC is perilous for the development of active treatment approaches. Hypoxia in cancer is linked with malignancy, and its phenotype is implicated in the hypoxic reaction, which is being studied as a prospective cancer treatment target. The hypervascularization of the tumor is the main feature of human LC, and hypoxia is a major stimulator of neo-angiogenesis. It was seen that low oxygen levels in human LC are a critical aspect of this lethal illness. However, as there is a considerable body of literature espousing the presumed functional relevance of hypoxia in LC, the direct measurement of oxygen concentration in Human LC is yet to be determined. This narrative review aims to show the importance and as a future target for novel research studies that can lead to the perception of LC therapy in hypoxic malignancies.

Keywords: Hypoxia, lung cancer, HIF-1α , oxygen measurements , positron emission tomography , neo-angiogenesis .

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