Title:In Situ Photo Responsive Biodegradable Nanoparticle Forming Intrauterine Implant for Drug Delivery to Treat Ovarian Diseases: A Rationale-based Review
Volume: 17
Issue: 4
Author(s): Leander Corrie*, Nagavendra Kommineni, Jaskiran Kaur, Ankit Awasthi, Raghunandan Gundaram and Latha Kukati
Affiliation:
- School of Pharmaceutical Sciences, Lovely Professional University, Phagwara 144411, Punjab, India
Keywords:
Ovary, intrauterine device, light sensitive, implants, biodegradable, targeted action.
Abstract: Ovarian disease constitutes various types of endocrine disorders, such as polycystic
ovarian syndrome (PCOS), ovarian cancer, premature ovarian failure, ovarian endometriosis,
and ovarian cysts. The prevalence of ovarian-related diseases is highly vulnerable in the world.
The utility of various drug delivery systems for ovarian diseases has resulted in varied success.
Moreover, most of them lead to severe adverse effects and are incapable of ameliorating the
signs and symptoms of the condition. Intrauterine devices (IUDs) have positioned themselves as
a mechanism to deliver the drug for various ovarian-related diseases. Thereby avoiding various
stability-related issues arising due to various physiological barriers of the female reproductive
tract. However, the use of intrauterine devices for drug delivery to the ovaries has not been fully
explored. This is attributed to the fact that they cause cysts in the ovaries and skepticism among
patients and physicians. Photo-sensitive devices are an appealing approach for managing disorders
affecting the ovaries. Photo-sensitive in situ forming intrauterine implants (IUIs) have several
advantages, including simplicity in application, reduced invasiveness, as well as improved
site-specific drug release control. Polymeric nanoparticles (PNPs) loaded with a drug may be a
suitable choice to provide sustained release, alter the pharmacokinetics, and reduce the dose and
dosing frequency. The current manuscript hypothesizes the utility of a PNP-loaded biodegradable
photo-responsive intrauterine implantable device as an alternate novel strategy for ameliorating
ovarian-related diseases.