Title:An Overview of Antihistamines and their Properties used for Treatment of
Different Diseases
Volume: 22
Issue: 4
Author(s): Riya Chaudhari*, Seema Gosavi, Pratiksha Bornare, Saurabh Sonawane and Tejas Ahire
Affiliation:
- Department of Quality Assurance Technique, Sanjivani College of Pharmaceutical Education and Research, At Sahajandnagar, Post- Shinganapur, Tal, Kopargaon, Dist-Ahmednagar, Maharashtra, 423603, India
Keywords:
Antihistamines, allergic rhinitis, late and early reaction, H1 and H2 receptor, COVID-19, sedative and non-sedative.
Abstract:
Background: By comparing the histamine impact to the instant response to an injected
foreign protein in previously sensitized animals, one might hypothesize that histamine
may be involved in this reaction. Through all four of the recognized types of histamine receptors,
histamine is also essential for the control of immunological function and acute and chronic
allergic inflammation.
Methods: Recent evidence points to anti-IgE antibodies and specific antibodies to cytokines
like IL-4 or IL-5 that are associated with allergic inflammation as probable causes of Allergic
Rhinitis. The therapeutic advantage of antihistamines is a decrease in allergy symptoms and
any other allergy-related symptoms. We research the many diseases and dose forms in which
antihistamines are used. Pediatric age groups have never been thoroughly studied for firstgeneration
antihistamines. Oral antihistamines are suggested as the first line of therapy for
people with mild to severe intermittent Allergic Rhinitis symptoms.
Results: Currently, approximately 100 different antihistamine-containing medicines and
around 20 different H1-receptor antagonists are available for therapeutic use. Antihistamines
of the second generation are more efficient and secure than those of the first generation. We
conducted a research on the sedative and non-sedative effects of antihistamines used to treat
various diseases.
Conclusion: The present investigation highlights the use of antihistamines in various diseases
at different ages, their sedative and non-sedative effect, and their utility in treating insomnia
based on their safety and current use among the patient population, as well as our observation.
