Title:Association of Cardiovascular Events with COVID-19 Vaccines Using
Vaccine Adverse Event Reporting System (VAERS): A Retrospective
Study
Volume: 19
Issue: 3
Author(s): Mohd Amir, S. Latha, Ruchika Sharma and Anoop Kumar*
Affiliation:
- Department of Clinical Research, Delhi Institute of Pharmaceutical Sciences and Research (DIPSAR), Delhi Pharmaceutical
Sciences and Research University (DPSRU), New Delhi, 110017, India
- Department of Pharmacology, Delhi
Institute of Pharmaceutical Sciences and Research (DIPSAR), Delhi Pharmaceutical Sciences and Research University
(DPSRU), New Delhi, 110017, India
Keywords:
COVID-19 vaccines, cardiovascular events, VAERS, Cov19VaxKB tool, myocardial infarction, AMI.
Abstract:
Background: COVID-19 vaccines have played a crucial role in reducing the burden of
the global pandemic. However, recent case reports have indicated the association of the COVID-
19 vaccines with cardiovascular events but the exact association is unclear so far.
Objective: Therefore, the objective of the current study is to find out the association of cardiovascular
events with COVID-19 vaccines.
Methods: The COVID-19 Vaccine Knowledge Base (Cov19VaxKB) tool was used to query the
Vaccine Adverse Event Reporting System (VAERS) database. The proportional reporting ratio
[PRR (≥2)] with associated chi-squared value (>4), and the number of cases > 0.2% of total
reports, was used to assess the association of COVID-19 vaccines with cardiovascular events.
Results: A total of 33,754 cases of cardiovascular events associated with COVID-19 vaccines
were found in the Cov19VaxKB tool. The cases were observed in different age groups (18-64,
and 65 years and above) and gender. The disproportionality measures indicate a statistically
significant association between cardiovascular events and COVID-19 vaccines.
Conclusion: The current study identified a signal of various cardiovascular events with the
COVID-19 vaccines. However, further causality assessment is required to confirm the association.
