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Protein & Peptide Letters

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Research Article

Investigation of Early Growth Response Protein (EGR) Levels in Patients with Fibromyalgia Syndrome: A Cross-Sectional Study

Author(s): Ayca Tas, Tugba Agbektas, Ahmet Karadag, Süleyman Aydin*, Emrullah Hayta and Yavuz Silig

Volume 30, Issue 12, 2023

Published on: 24 November, 2023

Page: [1001 - 1008] Pages: 8

DOI: 10.2174/0109298665256584231103113328

Price: $65

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Abstract

Background: Fibromyalgia is a soft tissue rheumatism characterized by chronic and widespread musculoskeletal pain at specific points in the body.

Objectives: In this study, we aimed to investigate the relationship between Early Growth Response (EGR1, EGR2, and EGR3) protein levels in patients with Fibromyalgia Syndrome (FMS) and healthy controls.

Methods: In our studies, 76 FMS patient group and 78 healthy control group who were newly diagnosed with primary FMS according to the 2010 American College of Rheumatology criteria for fibromyalgia in Sivas Cumhuriyet University Hospital, Physical Therapy, and Rehabilitation were used. Venous blood samples were taken from both groups for the measurement of EGR1, EGR2, and EGR3 protein plasma levels, and protein levels were determined using ELISA methods. Statistical parametric test assumptions were compared using the Independent Student's t-test. In addition, specificity, sensitivity, and AUC values were calculated with the ROC curve.

Results: The relationship between plasma EGR1 protein levels of FMS patients and control groups was statistically significant (p=0.001).

Conclusion: EGR1 protein levels were found to be lower in the patient group diagnosed with FMS compared to the control group. It has been suggested that EGR1 protein levels can be important in the diagnosis of FMS disease.

Keywords: Early growth response proteins, fibromyalgia, protein levels, ELISA, soft tissue rheumatism, musculoskeletal pain.

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Graphical Abstract

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