Identifying Dental Pulp Stem Cell as a Novel Therapeutic trategy for Digestive Diseases

Xieyin      Sun; Zhaoyi      Lin; Nuo      Xu; Yinqi      Chen; Saiyan      Bian; Wenjie      Zheng
doi:10.2174/011574888X275737231120045815
Abstract

Mesenchymal stem cells (MSCs) have been identified as potential therapeutics for various diseases. In contrast to other sources of MSCs, dental stem cells (DSCs) have received increased attention due to their high activity and easy accessibility. Among them, dental pulp stem cells (DPSCs) exhibit superior self-renewal, multipotency, immunomodulatory, and regenerative capacities. Following their inspiring performance in animal models and clinical trials, DPSCs show pharmacological potential in regenerative medicine. In this review, we have generalized the sources, heterogeneity, and biological characteristics of DPSCs, as well as compared them with other types of dental stem cells. In addition, we summarized the application of DPSCs in digestive diseases (such as liver, esophageal, and intestinal diseases), highlighting their regenerative and pharmacological potential based on the existing preclinical and clinical evidence. Specifically, DPSCs can be home to injured or inflamed tissues and exert repair and regeneration functions by facilitating immune regulation, anti-inflammation, and directional differentiation. Although DPSCs have a rosy prospect, future studies should handle the underlying drawbacks and pave the way for the identification of DPSCs as novel regenerative medicine.
Keywords: Dental pulp stem cell, pharmacological, digestive diseases, regenerative medicine, mesenchymal stem cells (MSCs), regenerative medicine.
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DOI https://dx.doi.org/10.2174/011574888X275737231120045815	Print ISSN 1574-888X
Publisher Name Bentham Science Publisher	Online ISSN 2212-3946
Current Stem Cell Research & Therapy

Identifying Dental Pulp Stem Cell as a Novel Therapeutic trategy for Digestive Diseases

Abstract

Graphical Abstract

Current Stem Cell Research & Therapy

Identifying Dental Pulp Stem Cell as a Novel Therapeutic trategy for Digestive Diseases

Abstract

Graphical Abstract

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