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Current Protein & Peptide Science

Editor-in-Chief

ISSN (Print): 1389-2037
ISSN (Online): 1875-5550

Review Article

Development and Challenges of Cyclic Peptides for Immunomodulation

Author(s): Xianqiong Jiang, Li Gao, Zhilong Li, Yan Shen and Zhi-Hua Lin*

Volume 25, Issue 5, 2024

Published on: 21 November, 2023

Page: [353 - 375] Pages: 23

DOI: 10.2174/0113892037272528231030074158

Price: $65

Abstract

Cyclic peptides are polypeptide chains formed by cyclic sequences of amide bonds between protein-derived or non-protein-derived amino acids. Compared to linear peptides, cyclic peptides offer several unique advantages, such as increased stability, stronger affinity, improved selectivity, and reduced toxicity. Cyclic peptide has been proved to have a promising application prospect in the medical field. In addition, this paper mainly describes that cyclic peptides play an important role in anti-cancer, anti-inflammatory, anti-virus, treatment of multiple sclerosis and membranous nephropathy through immunomodulation. In order to know more useful information about cyclic peptides in clinical research and drug application, this paper also summarizes cyclic peptides currently in the clinical trial stage and cyclic peptide drugs approved for marketing in the recent five years. Cyclic peptides have many advantages and great potential in treating various diseases, but there are still many challenges to be solved in the development process of cyclic peptides.

Keywords: Cyclic peptides, immunomodulation, immunity mechanisms, pharmacological activities, anti-inflammatory, multiple sclerosis.

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