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当代肿瘤药物靶点

Editor-in-Chief

ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

Research Article

柚皮素通过ROS介导的Bid和Bcl-xl信号通路诱导口腔癌细胞凋亡

卷 24, 期 6, 2024

发表于: 13 November, 2023

页: [668 - 679] 页: 12

弟呕挨: 10.2174/0115680096267430231023091521

价格: $65

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摘要

背景:口腔癌是一种影响大、预后差的恶性肿瘤。柚皮素是一种在柑橘类水果中发现的类黄酮,它的抗炎和抗氧化特性提供了潜在的治疗效果。然而,柚皮素对人舌癌CAL-27细胞的影响研究有限。本研究旨在阐明柚皮素与舌癌的相关性,从而确定一种潜在的舌癌药物干预候选药物。 方法:采用细胞计数试剂盒-8、JC-1线粒体膜电位测定、Annexin V—FITC细胞凋亡检测、细胞周期及凋亡分析、活性氧实验、Western blot等方法研究柚皮素对CAL-27细胞凋亡的影响及其机制。 结果:柚皮素显著诱导CAL-27细胞凋亡,且呈剂量依赖性。机制上,柚皮素通过上调Bid和下调Bcl-xl介导细胞凋亡,导致ROS生成增加。 结论:柚皮素可能通过调节Bid和Bcl-xl信号通路诱导凋亡细胞死亡,是治疗口腔癌的一个有希望的候选药物。

关键词: 柚皮素,口腔癌,ROS, Bid, Bcl-xl,信号通路,细胞凋亡。

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