An Insight into Emerging Phytocompounds for Glioblastoma Multiforme Therapy

Vijeta      Prakash; Reema      Gabrani
doi:10.2174/0118715257262003231031171910
Abstract

Despite intense research in the field of glioblastoma multiforme (GBM) therapeutics, the resistance against approved therapy remains an issue of concern. The resistance against the therapy is widely reported due to factors like clonal selection, involvement of multiple developmental pathways, and majorly defective mismatch repair (MMR) protein and functional O6- methylguanine DNA methyltransferase (MGMT) repair enzyme. Phytotherapy is one of the most effective alternatives to overcome resistance. It involves plant-based compounds, divided into several classes: alkaloids; phenols; terpenes; organosulfur compounds. The phytocompounds comprised in these classes are extracted or processed from certain plant sources. They can target various proteins of molecular pathways associated with the progression and survival of GBM. Phytocompounds have also shown promise as immunomodulatory agents and are being explored for immune checkpoint inhibition. Therefore, research and innovations are required to understand the mechanism of action of such phytocompounds against GBM to develop efficacious treatments for the same. This review gives insight into the potential of phytochemical-based therapeutic options for GBM treatment.
Keywords: Cell invasion, chemotherapy, drug resistance, GBM, migration, synergy, temozolomide, tyrosine kinase receptor.
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DOI https://dx.doi.org/10.2174/0118715257262003231031171910	Print ISSN 1871-5257
Publisher Name Bentham Science Publisher	Online ISSN 1875-6182
Cardiovascular & Hematological Agents in Medicinal Chemistry

An Insight into Emerging Phytocompounds for Glioblastoma Multiforme Therapy

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