Title:An Insight into the Protein Aggregation in Alzheimer’s Disease and its
Inhibition
Volume: 30
Issue: 11
Author(s): Abdul Basit Khan and Rizwan Hasan Khan*
Affiliation:
- Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh, Uttar Pradesh, India
Keywords:
Protein aggregation, protein misfolding, alzheimer’s disease, amyloidosis, neurodegeneration, inhibition.
Abstract: Alzheimer’s disease, a neurodegenerative disease, is a progressive and irreversible disease
that has become a global challenge due to its increasing prevalence and absence of available
potential therapies. Protein misfolding and aggregation are known to be the root of several protein
neurodegenerative diseases, including Alzheimer’s disease. Protein aggregation is a phenomenon
where misfolded proteins accumulate and clump together intra-or extracellularly. This accumulation
of misfolded amyloid proteins leads to the formation of plaquesin the neuronal cells, also
known as amyloid β plaques. The synthesis of amyloid β plaques and tau protein aggregation are
the hallmarks of Alzheimer’s disease. Potential therapeutics must be developed in conjunction
with an understanding of the possible root cause involving complex mechanisms. The development
of therapeutics that can inhibit protein misfolding and aggregation, involved in the pathogenesis
of Alzheimer's disease, could be one of the potential solutions to the disease.
