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Abstract
Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder affecting women worldwide. It refers to a condition that often has ‘poly’ liquid containing sacks around ovaries. It affects reproductive-aged females, giving rise to menstrual and related reproductive issues. PCOS is marked by hormonal imbalance, often resulting in hyperandrogenism. Women with PCOS might experience abnormal insulin activity and complications such as acne, mood swings, hirsutism, obesity, and infertility. The disease is linked with severe clinical ailments such as type 2 diabetes (T2DM), cardiovascular diseases (CVDs), and cancer. A faulty lifestyle, neuroendocrine factors, genetic causes, and androgen exposures often cause PCOS. The approach of society towards physiological problems such as PCOS in women is that it must be under the veil that is the ultimate barrier to the early diagnosis of PCOS. Thus, this review summarizes the causes, symptoms, pathophysiology, diagnosis, and possible treatment (medical, herbal, and lifestyle improvement, acupuncture, and bariatric surgery) related to PCOS.
Keywords: Polycystic ovaries, obesity, hormonal imbalance, infertility, hirusitism, menstrual cycle.
[http://dx.doi.org/10.1038/s41390-019-0615-1] [PMID: 31627209]
[http://dx.doi.org/10.1016/j.eurox.2019.100060] [PMID: 31403134]
[http://dx.doi.org/10.1111/j.1365-2265.2008.03329.x] [PMID: 18616705]
[http://dx.doi.org/10.1016/j.jsmc.2007.11.001] [PMID: 19255602]
[http://dx.doi.org/10.1016/j.fertnstert.2009.09.018] [PMID: 20117778]
[http://dx.doi.org/10.1097/00006254-198202000-00001] [PMID: 7033852]
[http://dx.doi.org/10.3390/ijms22042048] [PMID: 33669557]
[http://dx.doi.org/10.1210/endrev/bnaa010] [PMID: 32310267]
[http://dx.doi.org/10.1016/j.mce.2012.10.009] [PMID: 23079471]
[http://dx.doi.org/10.1016/j.metabol.2017.09.016] [PMID: 29024702]
[http://dx.doi.org/10.4103/0022-3859.40778] [PMID: 18480528]
[http://dx.doi.org/10.1210/jcem.84.1.5382] [PMID: 9920059]
[http://dx.doi.org/10.1210/js.2019-00078] [PMID: 31384717]
[http://dx.doi.org/10.1016/S0301-5629(00)00219-2] [PMID: 10996697]
[PMID: 17909612]
[http://dx.doi.org/10.1097/AOG.0000000000002698] [PMID: 29995717]
[http://dx.doi.org/10.26479/2019.0501.18]
[http://dx.doi.org/10.1111/j.1365-2265.1989.tb00457.x] [PMID: 2513151]
[http://dx.doi.org/10.1210/clinem/dgaa839] [PMID: 33211867]
[http://dx.doi.org/10.1016/S0889-8529(05)70071-2] [PMID: 10352920]
[http://dx.doi.org/10.1016/j.jsbmb.2018.04.008] [PMID: 29678491]
[http://dx.doi.org/10.2147/TACG.S200341] [PMID: 31920361]
[http://dx.doi.org/10.2165/00129785-200404020-00004] [PMID: 15059032]
[http://dx.doi.org/10.1186/s12958-016-0173-x] [PMID: 27423183] [PMCID: PMC4947298]
[http://dx.doi.org/10.1016/j.fertnstert.2008.06.035] [PMID: 18950759]
[http://dx.doi.org/10.1111/jcmm.16205] [PMID: 33369146]
[http://dx.doi.org/10.1186/s13048-022-01091-0] [PMID: 36631836] [PMCID: PMC9832677]
[http://dx.doi.org/10.1055/s-2007-1016294] [PMID: 9165656]
[http://dx.doi.org/10.1159/000479371] [PMID: 29156452]
[http://dx.doi.org/10.1155/2014/719050] [PMID: 25763405] [PMCID: PMC4334071]
[http://dx.doi.org/10.1111/j.1365-2265.2006.02587.x] [PMID: 16886951]
[http://dx.doi.org/10.1159/000194971] [PMID: 20054201]
[http://dx.doi.org/10.1177/1179558119874042] [PMID: 31523137]
[http://dx.doi.org/10.1186/s12902-020-0497-6] [PMID: 32000752]
[http://dx.doi.org/10.3109/09513590.2013.871517] [PMID: 24397396]
[http://dx.doi.org/10.1210/clinem/dgab474] [PMID: 34180998]
[http://dx.doi.org/10.1080/01443610701667338] [PMID: 18097891]
[http://dx.doi.org/10.22270/ajprd.v8i4.769]
[http://dx.doi.org/10.1016/j.ajog.2004.04.045] [PMID: 15467530]
[http://dx.doi.org/10.1016/S1472-6483(10)61770-1] [PMID: 15670405]
[http://dx.doi.org/10.1055/s-2002-36706] [PMID: 12536355]
[http://dx.doi.org/10.1111/jne.13093] [PMID: 35083794]
[http://dx.doi.org/10.1097/01.AOG.0000104485.44999.C6] [PMID: 14704263]
[http://dx.doi.org/10.1016/j.beem.2006.02.004] [PMID: 16772149]
[http://dx.doi.org/10.1097/MED.0b013e32832afd4d] [PMID: 19390322]
[http://dx.doi.org/10.1016/j.cca.2019.09.010] [PMID: 31525346]
[http://dx.doi.org/10.3390/ijms21218191] [PMID: 33139661]
[http://dx.doi.org/10.2147/IJWH.S344542] [PMID: 35140526] [PMCID: PMC8818772]
[http://dx.doi.org/10.1093/humrep/des213] [PMID: 22693172]
[http://dx.doi.org/10.3389/fendo.2020.00641] [PMID: 33013710] [PMCID: PMC7509053]
[http://dx.doi.org/10.1186/s12958-015-0134-9] [PMID: 26691645]
[http://dx.doi.org/10.1080/13813455.2018.1499120] [PMID: 30450993]
[http://dx.doi.org/10.1016/S0015-0282(03)00734-9] [PMID: 12909480]
[http://dx.doi.org/10.1080/13543784.2020.1781815] [PMID: 32543238]
[http://dx.doi.org/10.1111/j.1472-8206.2010.00916.x] [PMID: 21210850]
[http://dx.doi.org/10.1097/MOP.0000000000000778] [PMID: 31299022]
[PMID: 17426408]
[http://dx.doi.org/10.4103/0974-1208.106338] [PMID: 23531705]
[http://dx.doi.org/10.1159/000341824] [PMID: 24002410]
[http://dx.doi.org/10.1080/09513590.2017.1370644] [PMID: 28850273]
[http://dx.doi.org/10.1111/j.1365-2265.2008.03369.x] [PMID: 18691273]
[http://dx.doi.org/10.1136/bmj.327.7421.951] [PMID: 14576245]
[http://dx.doi.org/10.1056/NEJMct0707092] [PMID: 18172174]
[http://dx.doi.org/10.1016/S0015-0282(00)01766-0] [PMID: 11239532]
[http://dx.doi.org/10.1093/humrep/del185] [PMID: 16785260]
[http://dx.doi.org/10.1111/j.1479-828X.2012.01448.x] [PMID: 22639834]
[http://dx.doi.org/10.1016/j.fertnstert.2006.04.026] [PMID: 17070196]
[http://dx.doi.org/10.1016/j.jsbmb.2007.05.025] [PMID: 17604615]
[http://dx.doi.org/10.1093/humupd/dms003] [PMID: 22431566]
[http://dx.doi.org/10.2147/IJWH.S11304] [PMID: 21339935]
[http://dx.doi.org/10.1080/14767050600761893] [PMID: 16785142]
[http://dx.doi.org/10.1016/j.beem.2006.03.006] [PMID: 16772157]
[http://dx.doi.org/10.1016/S1472-6483(10)62107-4] [PMID: 15257815]
[http://dx.doi.org/10.3389/fsurg.2015.00030] [PMID: 26236709]
[http://dx.doi.org/10.1016/j.soard.2019.03.032] [PMID: 31113751]
[http://dx.doi.org/10.4239/wjd.v3.i4.71] [PMID: 22532886]
[http://dx.doi.org/10.1016/j.soard.2021.04.009] [PMID: 34006495]
[http://dx.doi.org/10.6061/clinics/2015(11)09] [PMID: 26602525]
[http://dx.doi.org/10.1016/j.ajog.2013.05.007] [PMID: 23659986]
[http://dx.doi.org/10.1093/oxfordjournals.humrep.a137313] [PMID: 1905314]
[http://dx.doi.org/10.7326/0003-4819-110-5-386] [PMID: 2492787]
[http://dx.doi.org/10.1530/EJE-10-0709] [PMID: 21156647]
[http://dx.doi.org/10.3949/ccjm.70.1.31] [PMID: 12549723]
[http://dx.doi.org/10.1016/S0015-0282(02)03101-1] [PMID: 12057718]
[http://dx.doi.org/10.3109/09513590.2012.754876] [PMID: 23327685]
[http://dx.doi.org/10.1016/j.beem.2006.02.002] [PMID: 16772160]
[http://dx.doi.org/10.1080/gye.17.1.57.63] [PMID: 12724020]
[http://dx.doi.org/10.1111/ijd.14370] [PMID: 30604525]
[http://dx.doi.org/10.1016/S0889-8529(05)70077-3] [PMID: 10352926]
[http://dx.doi.org/10.1080/13625187.2017.1317735] [PMID: 28463030]
[http://dx.doi.org/10.1034/j.1600-0412.2001.080008689.x] [PMID: 11531609]
[http://dx.doi.org/10.2165/00003495-199958001-00010] [PMID: 10576524]
[http://dx.doi.org/10.1111/j.1464-5491.2011.03460.x] [PMID: 21950959]
[http://dx.doi.org/10.2174/138161212803307590] [PMID: 22834924]
[http://dx.doi.org/10.1517/14728220903190699] [PMID: 19650762]
[http://dx.doi.org/10.1016/S0015-0282(98)00454-3] [PMID: 9988406]
[http://dx.doi.org/10.1210/jc.86.4.1626] [PMID: 11297595]
[http://dx.doi.org/10.3109/09513590.2010.491572] [PMID: 20528570]
[http://dx.doi.org/10.2165/00024677-200605030-00005] [PMID: 16677059]
[http://dx.doi.org/10.1592/phco.25.2.244.56943]
[http://dx.doi.org/10.1093/humrep/deg264] [PMID: 12773448]
[http://dx.doi.org/10.1210/jc.2008-1133] [PMID: 18984667]
[http://dx.doi.org/10.1093/humrep/deh145] [PMID: 14998947]
[http://dx.doi.org/10.1530/REP-09-0568] [PMID: 20395425]
[http://dx.doi.org/10.1016/j.bpobgyn.2014.11.001] [PMID: 25487256]
[http://dx.doi.org/10.1038/sj.ijo.0801994] [PMID: 12080440]
[http://dx.doi.org/10.1093/humupd/dmn043] [PMID: 18927072]
[http://dx.doi.org/10.1055/s-0032-1328878] [PMID: 23074008]
[http://dx.doi.org/10.1007/s12020-013-9971-5] [PMID: 23625194]
[http://dx.doi.org/10.1001/jama.293.23.2873] [PMID: 15956632]
[http://dx.doi.org/10.1007/s11154-014-9289-5] [PMID: 24811133]
[http://dx.doi.org/10.1001/jamapediatrics.2013.1045] [PMID: 23380890]
[http://dx.doi.org/10.7759/cureus.27689] [PMID: 36072214]
[http://dx.doi.org/10.1080/17446651.2021.1896966] [PMID: 33719818]
[http://dx.doi.org/10.1007/s11695-015-1902-5] [PMID: 26431698]
[http://dx.doi.org/10.1111/j.1399-5448.2012.00899.x] [PMID: 22830534]
[http://dx.doi.org/10.1016/j.ejogrb.2016.10.001] [PMID: 27773356]
[http://dx.doi.org/10.1007/s00464-011-1960-2] [PMID: 22179438]
[http://dx.doi.org/10.1016/j.amjsurg.2008.04.008] [PMID: 18954593]
[http://dx.doi.org/10.1001/archsurg.138.4.376] [PMID: 12686523]
[http://dx.doi.org/10.1210/jc.84.4.1470] [PMID: 10199797]
[http://dx.doi.org/10.1016/S1472-6483(10)61182-0] [PMID: 16790100]
[http://dx.doi.org/10.1016/S1043-2760(02)00612-4] [PMID: 12128286]
[http://dx.doi.org/10.1079/BJN20051475] [PMID: 16115348]
[http://dx.doi.org/10.1111/j.1365-277X.2009.00988.x] [PMID: 19735349]
[http://dx.doi.org/10.1186/s12887-020-02173-y] [PMID: 32498675]
[http://dx.doi.org/10.1016/j.ijgo.2012.01.027] [PMID: 22507264]
[http://dx.doi.org/10.1007/978-981-15-1792-1_8] [PMID: 32342454]
[http://dx.doi.org/10.3390/jfmk5020035] [PMID: 33467251]
[PMID: 32285088]
[http://dx.doi.org/10.1089/acm.2011.0868] [PMID: 22808940]
[http://dx.doi.org/10.1016/j.jbmt.2021.02.018] [PMID: 34391246]
[http://dx.doi.org/10.18502/ijrm.v17i12.5789] [PMID: 31970309]
[http://dx.doi.org/10.1177/1933719117711262] [PMID: 28558523]
[http://dx.doi.org/10.4103/0974-1208.126295] [PMID: 24672165]
[http://dx.doi.org/10.1016/j.rbmo.2012.10.007] [PMID: 23177415]
[http://dx.doi.org/10.1016/S1472-6483(11)60393-3] [PMID: 23577418]
[http://dx.doi.org/10.1016/j.steroids.2011.11.014] [PMID: 22182833]
[http://dx.doi.org/10.1055/s-0034-1375676] [PMID: 24941435]
[http://dx.doi.org/10.1093/humrep/dei104] [PMID: 16006454]
[http://dx.doi.org/10.1016/j.fertnstert.2004.07.960] [PMID: 15705376]
[http://dx.doi.org/10.1016/S0015-0282(02)03133-3] [PMID: 12057717]
[http://dx.doi.org/10.1080/00016340601090337] [PMID: 17364286]
[http://dx.doi.org/10.1002/jcph.362] [PMID: 25042908]
[http://dx.doi.org/10.1155/2020/6461254] [PMID: 32308679]
[PMID: 25010620]
[http://dx.doi.org/10.1016/j.rbmo.2016.08.024] [PMID: 27717596]
[http://dx.doi.org/10.1155/2016/1979654] [PMID: 27795706]
[http://dx.doi.org/10.3390/ijms20225787] [PMID: 31752081]
[http://dx.doi.org/10.3109/01443615.2012.751365] [PMID: 23550861]
[http://dx.doi.org/10.1186/s12958-018-0346-x] [PMID: 29580250]
[PMID: 28546815]
[http://dx.doi.org/10.1055/s-2007-992933] [PMID: 18181091]
[http://dx.doi.org/10.1210/jc.2013-2674] [PMID: 24152688]
[http://dx.doi.org/10.3390/jcm11154509] [PMID: 35956124]
[http://dx.doi.org/10.1016/j.ctcp.2012.01.005]
[http://dx.doi.org/10.1210/jc.2013-2350] [PMID: 24151290]
[http://dx.doi.org/10.1093/humrep/dey256] [PMID: 30052961]
[PMID: 21550045]
[PMID: 22178257]
[PMID: 25411807]
[http://dx.doi.org/10.1093/humupd/dmv029] [PMID: 26117684]
![Wayfinder Image](/images/wayfinder.jpg)