A Critical Review on Therapeutic Potential of Benzimidazole Derivatives:
A Privileged Scaffold

Ramalakshmi      Natarajan; Padma      Kumar; Arunkumar      Subramani; Amuthalakshmi      Siraperuman; Prabakaran      Angamuthu; Richie   R.   Bhandare; Afzal   B.   Shaik
doi:10.2174/0115734064253813231025093707
Abstract

Benzimidazole nucleus is a predominant heterocycle displaying a wide spectrum of pharmacological activities. The privileged nature of the benzimidazole scaffold has been revealed by its presence in most small molecule drugs and in its ability to bind multiple receptors with high affinity. A literature review of the scaffold reveals several instances where structural modifications of the benzimidazole core have resulted in high-affinity lead compounds against a variety of biological targets. Hence, this structural moiety offers opportunities to discover novel, better, safe and highly potent biological agents. The goal of the present review is to compile the medicinal properties of benzimidazole derivatives with a focus on SAR (Structure-Activity Relationships).
Keywords: Benzimidazole, privileged scaffold, structure-activity relationship, multiple targets, lead compounds, SAR.
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DOI https://dx.doi.org/10.2174/0115734064253813231025093707	Print ISSN 1573-4064
Publisher Name Bentham Science Publisher	Online ISSN 1875-6638
Medicinal Chemistry

A Critical Review on Therapeutic Potential of Benzimidazole Derivatives: A Privileged Scaffold

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