Tertiary Hyperparathyroidism and Extra Skeletal Calcification in End Stage Kidney Disease Patients: Case-series and Literature Review

Title:Tertiary Hyperparathyroidism and Extra Skeletal Calcification in End Stage Kidney Disease Patients: Case-series and Literature Review

Volume: 5

Author(s): Sanaa Majdi Alahbabi, Meera Ahmed Alshehhi, Rawdha Almeqdad Alkaabi, Fakhriya Alalawi*Amna Alhadari

Affiliation:

• Department of Nephrology, Dubai Academic Health Corporation (DAHC), Dubai, United Arab Emirates

Keywords: Tertiary hyperparathyroidism (THPT), Parathyroid Hormone (PTH), End-Stage Kidney Disease (ESKD), Brown tumour, Calciphylaxis, Dialysis.

Abstract:

Background: Tertiary hyperparathyroidism (THPT) is a well-known complication of end-stage kidney disease (ESKD), resulting from a loss of functional renal tissue with subsequent alterations in calcium and phosphate metabolism. Tertiary hyperparathyroidism reflects severe parathyroid hyperplasia with autonomous excessive secretion of parathyroid hormone (PTH) that is no longer responsive to the concentration of plasma calcium and leads to abnormal bone remodelling, soft tissue calcifications, vasculopathy, and other systemic complications.

Case Presentation: The authors, hereby, highlight varied presentations of tertiary hyperparathyroidism (THPT) by presenting 3 interesting cases, describing their clinical course and outcomes. Through sharing these experiences and insights, we hope to contribute to a better understanding of THPT and its optimal management in patients with ESKD.

Conclusion: THPT can have a significant impact on patient health and quality of life. Despite the widespread use of interventions, such as vitamin D analogues, calcimimetics and parathyroidectomy, THPT remains a significant clinical challenge for patients with ESKD.

Cite this article as:

Majdi Alahbabi Sanaa, Ahmed Alshehhi Meera, Almeqdad Alkaabi Rawdha, Alalawi Fakhriya*, Alhadari Amna, Tertiary Hyperparathyroidism and Extra Skeletal Calcification in End Stage Kidney Disease Patients: Case-series and Literature Review, New Emirates Medical Journal 2024; 5 : e02506882262902 . https://dx.doi.org/10.2174/0102506882262902231020110030