Title:Successful Pregnancy and Delivery after Premature Ovarian Insufficiency
Combined with Undifferentiated Connective Tissue Disease: A Case
Report
Volume: 24
Issue: 7
Author(s): Mengyang Du, Liying Peng, Ruixiu Zhang and Shihua Bao*
Affiliation:
- Shanghai Key Laboratory of Maternal-Fetal Medicine, Department of Reproductive Immunology, Shanghai Institute of
Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine,
Tongji University, Shanghai, 200092, China
Keywords:
Premature ovarian insufficiency (POI), undifferentiated connective tissue disease (UCTD), antinuclear, antiphospholipid antibodies, infertility, immunosuppressive agent, glucocorticoid, case report.
Abstract:
Background: Premature ovarian insufficiency (POI) is extremely rare in the early
stage of undifferentiated connective tissue disease. Patients with POI find it difficult to achieve
successful pregnancy and delivery.
Case Presentation: A 27-year-old female visited an outpatient department for premature ovarian
insufficiency (POI) and infertility. She had regular menstrual periods since she was 14 years
old and had no history of systemic disease. Laboratory tests showed low estrogen (15 ng/L,
range 19.6-144.2 ng/L), elevated follicle-stimulating hormone (34 U/L), low anti-Mullerian
hormone (0.1 μg/L), normal prolactin (11.48 ng/mL), and thyroid stimulating hormone (TSH)
levels (0.97 mU/L). She demonstrated smaller bilateral ovarian volume and positivity to antinuclear
and antiphospholipid antibodies. After the failure of conventional drug therapy and in vitro
fertilization, the patient became pregnant naturally after treatment with glucocorticoids.
Conclusion: Immunosuppression could help improve ovarian function and pregnancy outcomes
in POI patients, but the therapeutic mechanisms are not clear and should be elucidated with
more clinical studies.
