Title:Comparison between the ECG Outcomes of Metoprolol and Bisoprolol
Volume: 22
Issue: 4
Author(s): Ahmad Abdulrahman Almeman*, Yousef Obaid Alharbi*, Abdulaziz Sulaiman Alwahhabi, Abdulaziz Abdullah Almutairi, Moayad Yousef Alnasr and Abdulrahaman Almesnid
Affiliation:
- Department of Pharmacology, College of Medicine, Prince Sultan Cardiac Center, Qassim University, Buraydah, Qassim,
Saudi Arabia
- College of Medicine, Qassim University, Buraydah, Qassim, Saudi Arabia
Keywords:
Beta-blockers, cardiovascular diseases, metoprolol, bisoprolol, ECG, pharmacogenetics.
Abstract:
Background: Beta-blockers are essential agents in the management of cardiovascular
diseases, such as heart failure, acute myocardial infarction (MI), and cardiac arrhythmias. However,
there are diurnal variations in the cardioprotective effects of the subgroups as a result of
their different pharmacokinetic, pharmacodynamic, and pharmacogenetic profiles.
Objectives: We aimed to compare metoprolol and bisoprolol in terms of electrocardiogram
(ECG) outcomes.
Methods: A retrospective cross-sectional study was conducted at Prince Sultan Cardiac Center.
The trial included 404 patients who met the inclusion criteria (204 in the metoprolol arm and 200
in the bisoprolol arm). Using case record forms that had already been created, information, such
as patient demographics, medical histories, and treatment histories, was taken from their medical
files. The most recent ECG records were also gathered. The ethical approval for this study was
obtained from Qassim ethical committee (approval number: 45-44-902).
Results: There was no significant difference found between the patients in both arms in terms of
baseline characteristics, age, or sex.
Conclusion: In this retrospective cross-sectional study, we have compared the effects of
metoprolol and bisoprolol beta blockers on ECG changes. The findings have indicated no difference
between metoprolol and bisoprolol groups in terms of all ECG readings, particularly
PR/ms, QTC-ms, and ventricular rate. Further studies are required to confirm these findings.
