Title:Wound Healing, Anti-inflammatory and Antioxidant Potential of Quercetin
Loaded Banana Starch Nanoparticles
Volume: 22
Issue: 4
Author(s): Dharmendra Kumar*Pramod Kumar Sharma
Affiliation:
- Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University, Greater Noida, Uttar Pradesh, India
Keywords:
Banana starch nanoparticles, quercetin loaded nanoparticles, antioxidant nanoparticles, anti-inflammatory nanoparticles, quercetin wound healing activity, immune system.
Abstract:
Background: Quercetin belongs to the BCS Class IV of drugs, which means it exhibits
low solubility and low permeability. Quercetin is a potent antioxidant drug candidate, but
it has several drawbacks, such as a short half-life, poor stability, bioavailability, and solubility.
These factors affect its reliability as a good wound-healing, anti-inflammatory, and antioxidant
agent. Quercetin nanoparticles resolved these problems and offered high stability, high encapsulation
efficacy, sustained and prolonged release, and enhanced accumulation at target sites
with high therapeutic efficacy.
Methods: Banana starch and quercetin were used to formulate a new composition of nanoparticles.
Formulated QBSN were evaluated for their antioxidant, wound healing, and anti-inflammatory
potential.
Results: QBSN showed a good antioxidant effect against the DPPH free radical scavenging
model. Inhibition of DPPH free radicals reached up to 98 percent at 40 μl. Histopathological
studies of treated tissues (wound and paw edema) confirmed the potential of QBSN.
Conclusion: In the future, prepared nanoparticles may be the choice of drug formulation for
wound healing, anti-inflammatory therapy, and antioxidant therapy.
