Login Register Cart 0
Generic placeholder image

Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1871-5230
ISSN (Online): 1875-614X

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Research Article

Wound Healing, Anti-inflammatory and Antioxidant Potential of Quercetin Loaded Banana Starch Nanoparticles

Author(s): Dharmendra Kumar* and Pramod Kumar Sharma

Volume 22, Issue 4, 2023

Published on: 26 October, 2023

Page: [230 - 235] Pages: 6

DOI: 10.2174/0118715230252770231020060606

Price: $65

Abstract

Background: Quercetin belongs to the BCS Class IV of drugs, which means it exhibits low solubility and low permeability. Quercetin is a potent antioxidant drug candidate, but it has several drawbacks, such as a short half-life, poor stability, bioavailability, and solubility. These factors affect its reliability as a good wound-healing, anti-inflammatory, and antioxidant agent. Quercetin nanoparticles resolved these problems and offered high stability, high encapsulation efficacy, sustained and prolonged release, and enhanced accumulation at target sites with high therapeutic efficacy.

Methods: Banana starch and quercetin were used to formulate a new composition of nanoparticles. Formulated QBSN were evaluated for their antioxidant, wound healing, and anti-inflammatory potential.

Results: QBSN showed a good antioxidant effect against the DPPH free radical scavenging model. Inhibition of DPPH free radicals reached up to 98 percent at 40 μl. Histopathological studies of treated tissues (wound and paw edema) confirmed the potential of QBSN.

Conclusion: In the future, prepared nanoparticles may be the choice of drug formulation for wound healing, anti-inflammatory therapy, and antioxidant therapy.

Keywords: Banana starch nanoparticles, quercetin loaded nanoparticles, antioxidant nanoparticles, anti-inflammatory nanoparticles, quercetin wound healing activity, immune system.

« Previous Next »
Graphical Abstract

[1]
Chaniad, P.; Tewtrakul, S.; Sudsai, T.; Langyanai, S.; Kaewdana, K. Anti-inflammatory, wound healing and antioxidant potential of compounds from Dioscorea bulbifera L. bulbils. PLoS One, 2020, 15(12), e0243632.
[http://dx.doi.org/10.1371/journal.pone.0243632] [PMID: 33306733]
[2]
Wild, T.; Rahbarnia, A.; Kellner, M.; Sobotka, L.; Eberlein, T. Basics in nutrition and wound healing. Nutrition, 2010, 26(9), 862-866.
[http://dx.doi.org/10.1016/j.nut.2010.05.008] [PMID: 20692599]
[3]
Parasuraman, S.; Anand David, A.V.; Arulmoli, R. Overviews of biological importance of quercetin: A bioactive flavonoid. Pharmacogn. Rev., 2016, 10(20), 84-89.
[http://dx.doi.org/10.4103/0973-7847.194044] [PMID: 28082789]
[4]
Dharmendra, K.; Pramod, S.K. Quercetin: A comprehensive review. Curr. Nutr. Food Sci., 2023, 19.
[5]
Dharmendra, K.; Pramod, S.K. Formulation and evaluation of quercetin-loaded banana starch nanoparticles. Nanosci. Nanotechnol. Asia, 2023, 13.
[6]
Xu, D.; Hu, M.J.; Wang, Y.Q.; Cui, Y.L. Antioxidant activities of quercetin and its complexes for medicinal application. Molecules, 2019, 24(6), 1123.
[http://dx.doi.org/10.3390/molecules24061123] [PMID: 30901869]
[7]
Dharmendra, K.; Rishabha, M.; Pramod, S.K.; Akanksha, S.; Vineet, B. Advancement in nano pharmaceutical formulations and their biomedical use. Nanosci. Nanotechnol. Asia, 2021, 11(3)
[8]
Farrag, Y.; Ide, W.; Montero, B.; Rico, M.; Rodríguez-Llamazares, S.; Barral, L.; Bouza, R. Preparation of starch nanoparticles loaded with quercetin using nanoprecipitation technique. Int. J. Biol. Macromol., 2018, 114, 426-433.
[http://dx.doi.org/10.1016/j.ijbiomac.2018.03.134] [PMID: 29580996]
[9]
Kumar, Dharmendra; Sharma, Pramod Kumar Anthelmintic antimicrobial and antioxidant activity of different part of Indian origin Salvadora persica. Jour. of Med. P’ceutical& Alli. Sci.,, 2021, 10 - I 3(1088), 2728-2736.
[http://dx.doi.org/10.22270/jmpas.v10i3.1088]
[10]
Milanezi, F. G.; Meireles, M.; Malavazi de Christo, S.; Jairo, P.; Oliveira, D.; Andre Romero da, S.; Mariceli Lamas de, A.; Denise Coutinho, E.; Marcio, F.; Marco Cesar Cunegundes, G.; Rodrigo, S. Antioxidant, antimicrobial and cytotoxic activities of gold nanoparticles capped with quercetin. Saudi Pharmaceutical. J., 2019, 27(7), 968-974.
[11]
Juan de Dios, F.; Camila Marinho Mano, J.; Etelvino, H. Bechara,Luis, A.; Godínez, S.M. Hector Pool David Quintanar. Antioxidant effects of quercetin and catechin encapsulated into PLGA nanoparticles; J. Nanomat, 2012, p. 12.
[12]
Chahardoli, A.; Hajmomeni, P.; Ghowsi, M.; Qalekhani, F.; Shokoohinia, Y.; Fattahi, A. Optimization of quercetin‐assisted silver nanoparticles synthesis and evaluation of their hemocompatibility, antioxidant, anti‐inflammatory, and antibacterial effects. Glob. Chall., 2021, 5(12), 2100075.
[http://dx.doi.org/10.1002/gch2.202100075] [PMID: 34938575]
[13]
Kumar, D; Sharma, P. K. Extraction and evaluation of salvadora persica bark extract for its antioxidant and antimicrobial activity. Biosc. Biotech. Res. Comm. , 2020, 12(12)
[http://dx.doi.org/10.21786/bbrc/13.2/57]
[14]
Reena, B.; Bharti, M.; Yub Raj, N.; Kushagra, K.; Harvinder, P. Quercetin loaded silver nanoparticles in hydrogel matrices for diabetic wound healing. Nanotechnology, 2021, 32(50)
[15]
Hafiz, Muhammad Usman Abid; Hanif, Muhammad.; Mahmood, Khalid.; Aziz, Mubashir.; Abbas, Ghulam. Latif, Hafsa Woundhealing and antibacterial activity of the quercetin-4-formyl phenyl boronic acid complex against bacterial pathogens of diabetic foot ulcer. ACS Omega, 2022, 7(28), 24415-24422.
[16]
Nalini, T.; Khaleel Basha, S.; Mohamed Sadiq, A.; Sugantha Kumari, V. Fabrication and evaluation of nanoencapsulated quercetin for wound healing application. Polym. Bull., 2023, 80(1), 515-540.
[http://dx.doi.org/10.1007/s00289-022-04094-5]

Rights & Permissions Print Cite
Article Metrics
18
2
© 2024 Bentham Science Publishers | Privacy Policy