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Mini-Review Article

肾素受体-疾病网络中的一个调节节点

卷 24, 期 14, 2023

发表于: 25 October, 2023

页: [1093 - 1098] 页: 6

弟呕挨: 10.2174/0113894501250617231016052930

价格: $65

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摘要

实验性抑制(原)肾素受体[(P)RR]是一种很有前景的治疗策略，适用于从心肾到肿瘤等不同疾病模型。在这里，我们简要回顾了(P)RR的直接蛋白-蛋白相互作用伙伴以及(P)RR参与的大量不同疾病。Ebihara等人最近发表了使用AlphaFold对(P)RR进行的第一次结构研究，这是本迷你综述的中心，因为它可以将蛋白质-蛋白质相互作用水平与病理生理水平机械地联系起来。更详细地了解(P)RR的3D结构及其相互作用域可能会指导针对这一新靶点的药物发现。最后，简要讨论了基于抗体和小分子的抑制(P)RR的方法。

关键词: (Pro)肾素受体(P)RR，蛋白蛋白相互作用伙伴，AlphaFold，药物靶点，肿瘤学，心肾学。

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