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Current Organic Chemistry

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ISSN (Print): 1385-2728
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Mini-Review Article

Recent Developments in the Transformation of 3-amino-2-azetidinones

Author(s): Priyanka Sharma, Rashmi Sharma, Vipan Kumar, Parvesh Singh and Gaurav Bhargava*

Volume 27, Issue 19, 2023

Published on: 25 October, 2023

Page: [1651 - 1676] Pages: 26

DOI: 10.2174/0113852728253450231011052201

Abstract

Functionalized 3-amino-2-azetidinones are important heterocyclic systems which can easily be transformed into functionally decorated heterocycles using β-lactam synthon protocol. The different synthetic methods have been explored for the transformation of functionalized 3-amino-2-azetidiones to various heterocyclic molecules, such as imidazolidin-2-ones, piperazines, hydantoins, 4-oxo-1H-pyrroles, 1,4-benzodiazepin-2-ones, amino pyrrolidine-2- carboxylates etc., and β-lactam- based conjugates having diverse biological activities, such as anti-malarial activity, anti-tuberculosis, anti-trichomonas activity etc. The present review article summarizes the various reports on the synthetic transformation of functionalized 3-amino-2- azetidinones for the synthesis of a variety of heterocyclic systems.

Keywords: β-lactam, 3-amino-2-azetidinones, β-lactam synthon methodology, imidazolidin-2-ones, 1, 2, 3-triazole tethered-β-lactam, thiazolidinone, 4-aminoquinoline-β-lactam.

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Graphical Abstract

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