Title:Pharmacological Potential of Sulindac and Its Active Metabolite: A
Comprehensive Review
Volume: 19
Issue: 7
Author(s): Shraddha Manish Gupta, Ashok Behera*Siddharth Singh
Affiliation:
- Faculty of Pharmacy, DIT University, Dehradun, India
Keywords:
Sulindac, chemical transformations, clinical studies, sulindac sulfide, sulindac sulfone, pharmacokinetic profile.
Abstract: In this review, we describe and discuss the pharmaceutical aspects, pharmacokinetic profile,
and preclinical and clinical studies of sulindac and its active metabolite and emphasise their
potential activity not only in anti-inflammation strategies but also as chemoprevention drug candidates.
Though they are widely validated through in vitro and in vivo models, to date, no efforts have
been made to compile in a single review on their pharmacologically potential, pharmacokinetics and
toxicity profiles. Key databases such as PubMed, Science Direct, Scopus, and Google Scholar, among
others, were probed for a systematic search using keywords to retrieve relevant publications. An exhaustive
electronic survey of the related literature on the pharmacologically potential activity and the
pharmacokinetic and toxicity profiles of sulindac resulted in around 200 articles (1975 and 2023)
being included. The studies conducted on sulindac sulphide and sulindac sulfone metabolites reported
a varied range of biological effects deployed in this review. The review concluded that there is scope
for repurposing sulindac using computer-aided drug design and biological study to find out possible
new targets for strengthening the potency and selectivity of the metabolites.
