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Review Article

A Review on recent approaches for the use of different Analytical Techniques to Analyze some Calcium Channel Blockers and their Combinations with other Antihypertensive Drugs

Author(s): Saylee Ganorkar, Nilesh Kulkarni and Rahul Khiste*

Volume 1, 2023

Published on: 23 October, 2023

Article ID: e2210299X250401 Pages: 28

DOI: 10.2174/012210299X250401231010114247

open_access

Abstract

Background: Diabetes, high cholesterol, and high blood pressure all considerably raise the risk of cardiovascular disease. When all three of these characteristics occur at once, a metabolic problem is postulated. A combination of antihypertensive, hypolipidemic, and anti-diabetic medications is frequently utilised to treat cardiovascular diseases. While statins (fluvastatin, simvastatin, etc.) are used to lower cholesterol levels, calcium channel blockers (e.g. amlodipine, efonidipine, and azelnidipine, etc.) are used to target the smooth muscles of the heart. Diuretics (e.g. chlortalidone, hydrochlorothiazide, etc.) and angiotensin II receptor antagonist (blockers) are also used to manage high blood pressure.

Objective: The study aimed to review liquid chromatography and related high-performance (HPLC) techniques that have been developed and used for evaluating the above drugs, together with an overview of the research work published in various scientific and drugs-linked journals.

Results: A basic critical investigation of the detailed published information has been completed and the current status of HPLC and related techniques as a percent measure of calcium channel blockers has been examined.

Conclusion: This survey has explored several matrices, including pharmacological products and organic samples, as well as methods for examining direct calcium blockers in them. It also discusses the current state of calcium channel blocker stability investigations. Additionally, it offers scientific approaches for the concurrent estimate of angiotensin II receptor antagonism, diuretics, statins, and beta-blockers with calcium channel blockers.

Keywords: HPLC, Azelnidipine, Efonidipine, Cilnidipine, Calcium channel blockers (CCBs), Diabetes.

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