Regulating miRNAs Expression by Resveratrol: Novel Insights based on
Molecular Mechanism and Strategies for Cancer Therapy

Atoosa      Keshavarzmotamed; Vahide      Mousavi; Niloufar      Masihipour; Atefe      Rahmati; Rohollah      Mousavi Dehmordi; Behrooz      Ghezelbash; Mina      Alimohammadi; Alireza      Mafi
doi:10.2174/0118761429249717230920113227
Abstract

Resveratrol, a polyphenolic phytoalexin found in a wide range of plants, including grapes, berries, and peanuts, is an extensively researched phytochemical with unique pharmacological capabilities and amazing potential to affect many targets in various cancers. Resveratrol's anti-cancer activities are due to its targeting of a variety of cellular and molecular mechanisms and crucial processes involved in cancer pathogenesis, such as the promotion of growth arrest, stimulation of apoptosis, suppression of cell proliferation, induction of autophagy, regulating oxidative stress and inflammation, and improving the influence of some of the other chemotherapeutic agents. MicroRNAs (miRNAs) are non-coding RNAs that modulate gene expression by degrading mRNA or inhibiting translation. MiRNAs serve critical roles in a wide range of biological activities, and disruption of miRNA expression is strongly linked to cancer progression. Recent research has shown that resveratrol has anti-proliferative and/or pro-apoptotic properties via modulating the miRNA network, which leads to the inhibition of tumor cell proliferation, the activation of apoptosis, or the increase of traditional cancer therapy effectiveness. As a result, employing resveratrol to target miRNAs will be a unique and potential anticancer approach. Here, we discuss the main advances in the modulation of miRNA expression by resveratrol, as well as the several miRNAs that may be influenced by resveratrol in different types of cancer and the significance of this natural drug as a promising strategy in cancer treatment.
Keywords: MiRNA, Resveratrol, Cancer, Therapy, Signaling pathway, MMP. Article
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DOI https://dx.doi.org/10.2174/0118761429249717230920113227	Print ISSN 1874-4672
Publisher Name Bentham Science Publisher	Online ISSN 1874-4702
Current Molecular Pharmacology

Regulating miRNAs Expression by Resveratrol: Novel Insights based on Molecular Mechanism and Strategies for Cancer Therapy

Abstract

Advances in the Diagnosis and Treatment of Head and Neck Disease

Common Mechanisms Underpinning Neurodevelopmental Disorders and Psychiatric Diseases

New Cell Death Regulation Drugs for Cardiovascular Diseases

Current Molecular Pharmacology

Regulating miRNAs Expression by Resveratrol: Novel Insights based on Molecular Mechanism and Strategies for Cancer Therapy

Abstract

Call for Papers in Thematic Issues

Advances in the Diagnosis and Treatment of Head and Neck Disease

Common Mechanisms Underpinning Neurodevelopmental Disorders and Psychiatric Diseases

New Cell Death Regulation Drugs for Cardiovascular Diseases

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