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Review Article

Understanding Alzheimer’s Disease and its Metal Chelation Therapeutics: A Narrative Review

Author(s): Ritik Thakur, Ritu Karwasra and Tarana Umar*

Volume 29, Issue 30, 2023

Published on: 19 October, 2023

Page: [2377 - 2386] Pages: 10

DOI: 10.2174/0113816128263992231012113847

Price: $65

Abstract

The neurodegenerative disorders are age-related illnesses that cause the morphology or activity of neurons to deteriorate over time. Alzheimer’s disease is the most frequent neurodegenerative illness in the long run. The rate of advancement might vary, even though it is a progressive neurological illness. Various explanations have been proposed, however the true etiology of Alzheimer’s disease remains unclear. Most pharmacological interventions are based on the cholinergic theory, that is earliest idea. In accordance with the amyloid hypothesis, the buildup of beta-amyloid in brain regions is the primitive cause of illness. There is no proof that any one strategy is useful in avoiding Alzheimer’s disease, though some epidemiological studies have suggested links within various modifiable variables, such as cardiovascular risk, diet and so on. Different metals like zinc, iron, and copper are naturally present in our bodies. In metal chelation therapy drugs are used to jam the metal ions from combining with other molecules in the body. Clioquinol is one of the metal chelation drugs used by researchers. Research on metal chelation is still ongoing. In the present review, we go over the latest developments in prevalence, incidence, etiology, or pathophysiology of our understanding of Alzheimer’s disease. Additionally, a brief discussion on the development of therapeutic chelating agents and their viability as Alzheimer’s disease medication candidates is presented. We also assess the effect of clioquinol as a potential metal chelator.

Keywords: Neurodegenerative diseases, Alzheimer’s diseases, neurons, metal chelation therapy, clioquinol, chelator.

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