Title:Effects of Tirofiban in Patients with Acute Myocardial Infarction and
Diabetes Mellitus undergoing Primary Percutaneous Coronary Intervention
Volume: 22
Issue: 1
Author(s): Xiuying Tang*Runjun Li
Affiliation:
- Department of Cardiology, The First Hospital of QinHuangDao, QinHuangDao, 066000 HeBei, China
Keywords:
Acute myocardial infarction, myocardial perfusion index, thrombus aspiration, tirofiban, heart function, inflammatory factors.
Abstract:
Objective: This study evaluated the efficacy and safety of early vs. late tirofiban administration
in the treatment of patients with acute ST-elevation myocardial infarction (STEMI) and diabetes
mellitus (DM) undergoing primary percutaneous coronary intervention (pPCI).
Methods: 120 patients with STEMI and DM treated with pPCI were randomly divided into an observation
group (n=60) and a control group (n=60). The observation group and the control group were
intravenously injected with a bolus of tirofiban preoperatively or intraoperatively, respectively; both
groups were then given an intravenous infusion over 24 h at 0.15 μg/kg/min. Thrombolysis in myocardial
infarction (TIMI) grade flow, myocardial perfusion index, and functional heart parameters, as
well as major adverse cardiovascular events and bleeding, were compared between the two groups.
Results: Functional heart parameters, including left ventricular ejection fraction and cardiac output,
were significantly improved in the observation group 6 months after discharge. Thrombus aspiration,
inflammatory factors, and cardiac troponin I (cTNI) were more significantly decreased in the observation
group than in the control group. The sum-ST-segment elevation at 2 h after pPCI treatment in
the observation group was better than that in the control group. There was no significant difference in
the incidence of adverse reactions and bleeding between the two groups.
Conclusion: The administration of tirofiban before reperfusion therapy compared with after reperfusion
therapy is more effective in reducing the hyperthrombotic load, thrombus aspiration, inflammatory
factors, and cTNI and can effectively improve myocardial perfusion and heart function.
