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Current Pharmaceutical Biotechnology

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ISSN (Online): 1873-4316

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Review Article

Articulating the Pharmacological and Nanotechnological Aspects of Genistein: Current and Future Prospectives

Author(s): Keshav Bansal*, Vanshita Singh, Samiksha Mishra and Meenakshi Bajpai

Volume 25, Issue 7, 2024

Published on: 18 October, 2023

Page: [807 - 824] Pages: 18

DOI: 10.2174/0113892010265344230919170611

Price: $65

Abstract

Throughout the past several centuries, herbal constituents have been the subject of scientific interest and the latest research into their therapeutic potential is underway. Genistein is a soy-derived isoflavone found in huge amounts in soy, along with the plants of the Fabaceae family. Scientific studies have demonstrated the beneficial effects of genistein on various health conditions. Genistein presents a broad range of pharmacological activities, including anticancer, neuroprotective, cardioprotective, antiulcer, anti-diabetic, wound healing, anti-bacterial, antiviral, skin, and radioprotective effects. However, the hydrophobic nature of genistein results in constrained absorption and restricts its therapeutic potential. In this review, the number of nanocarriers for genistein delivery has been explored, such as polymeric nanoparticles, nanostructured lipid carriers, solid lipid nanoparticles, liposomes, micelles, transferosomes, and nanoemulsions and nanofibers. These nano-formulations of genistein have been utilized as a potential strategy for various disorders, employing a variety of ex vivo, in vitro, and in vivo models and various administration routes. This review concluded that genistein is a potential therapeutic agent for treating various diseases, including cancer, neurodegenerative disorders, cardiovascular disorders, obesity, diabetes, ulcers, etc., when formulated in suitable nanocarriers.

Keywords: Genistein, drug delivery, nano-formulations, isoflavone, pharmacological actions, nanocarriers.

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