Title:The Possible Association of IL-6R Gene Polymorphisms in the
Development of Diabetic Nephropathy
Volume: 20
Issue: 8
Author(s): Ebrahim Ebrat, Seyyedeh Mina Hejazian, Elham Ahmadian, Sepideh Zununi Vahed, Majid Mobasseri and Mohammadreza Ardalan*
Affiliation:
- Kidney Research Center, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
Keywords:
Type 2 diabetes (T2D), diabetic nephropathy (DN), Gene polymorphism, IL-6R gene, cytokine, chronic inflammation.
Abstract:
Background: Diabetic nephropathy (DN) is a common complication of type 2 diabetes
(T2D). Chronic inflammation and a combination of environmental and genetic factors are involved
in the pathogenesis and development of DN.
Objective: This case-control study aimed to determine the relationship between rs7529229 and
rs2228145 polymorphisms of the IL-6R gene with the incidence of nephropathy among T2D patients.
Methods: Fifty-six diabetic patients with nephropathy and 57 T2D patients without nephropathy
were included based on inclusion criteria, along with 150 healthy individuals.
Results: The frequencies of AC and CC genotype distributions of the rs2228145 polymorphism
in DN patients were significantly higher than in healthy individuals (24.1 and 9.3% versus 10.7
and 6.7%, respectively, P= 0.02). Moreover, the frequency of allele C was higher in DN patients
compared to healthy controls (21.30% versus 12%, P=0.025). However, genotype distribution
and allele frequencies of the rs7529229 IL-6R polymorphism in DN patients were not statistically
significant in comparison with diabetic patients and healthy individuals (P> 0.05).
Conclusion: The results showed that the allele and genotype distribution frequencies of
rs2228145 IL-6R gene polymorphism in patients with DN were significantly higher than in
healthy individuals. Therefore, the presence of this polymorphism may be involved in the development
of diabetic nephropathy in this population.
