Title:A Glance on Nanovaccine: A Potential Approach for Disease Prevention
Volume: 25
Issue: 11
Author(s): Akash Garg, Rutvi Agrawal*, Himansu Chopra, Talever Singh, Ramkumar Chaudhary and Abhishek Tankara
Affiliation:
- Department of Pharmaceutics, Rajiv Academy for Pharmacy, NH-2, Mathura-Delhi Road, P.O Chhatikara, Mathura,
281001, Uttar Pradesh, India
Keywords:
Vaccine, nanovaccine, immune response, infectious diseases, humoral, cell-mediated.
Abstract: There are several vaccines available for preventing various bacterial and viral infections,
but still, there are many challenges that require the development of noninvasive, more
efficient, and active vaccines. The advancement in biotechnological tools has provided safer
antigens, such as nucleic acids, proteins etc., but due to their lower immunogenic property, adjuvants
of stronger immune response are required. Nanovaccines are effective vaccines when compared
with conventional vaccines as they can induce both Humoral and cell-mediated immune
responses and also provide longer immunogenic memory. The nanocarriers used in vaccines act
as adjuvant. They provide site-specific delivery of antigens and can be used in conjugation with
immunostimulatory molecules for enhancing adjuvant therapy. The nanovaccines avoid degrading
cell pathways and provide effective absorption into blood vessels. The higher potential of
nanovaccines to treat various diseases, such as acquired immuno deficiency syndrome, cancer,
tuberculosis, malaria and many others, along with their immunological mechanisms and different
types, have been discussed in the review.