Login Register Cart 0
Generic placeholder image

Current Nutrition & Food Science

Editor-in-Chief

ISSN (Print): 1573-4013
ISSN (Online): 2212-3881

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Mini-Review Article

A Narrative Review on the Potential of Black Seeds (Nigella Sativa) in the Management of West Nile Virus Infection

Author(s): Naina Mohamed Pakkir Maideen, Rajkapoor Balasubramanian* and Arun Shanmugam

Volume 20, Issue 8, 2024

Published on: 10 October, 2023

Page: [908 - 913] Pages: 6

DOI: 10.2174/0115734013251160230921114603

Price: $65

conference banner
Abstract

West Nile virus (WNV) infection is a mosquito-borne illness that is endemic to Africa, Asia, the Middle East, Australia, and Europe. WNV-infected individuals can only be managed with symptomatic therapy and supportive care at this point of time. Thus, we have analyzed the possible beneficial effects of black seeds (N. sativa) in this literature review. To find relevant articles, various online databases, such as the Web of Science, Medline, PMC, PubMed, Embase, EBSCO, Google Scholar, Science Direct, and reference lists were searched. The antiviral, analgesic, anti-inflammatory, antioxidant, and immunomodulatory effects of black seeds (N. sativa) have been established by numerous clinical, animal, in vivo, in vitro, and in silico studies. It has been found that black seeds (N. sativa) have the potential to be included as adjuvant therapy in addition to symptomatic treatment and supportive care in the early stages of WNV infection once randomized controlled clinical trials (RCTs) affirm the safety and efficacy of black seeds (N. sativa) in WNV infection management as they have been considered the gold standard of treatment in clinical studies.

Keywords: Black seeds, Nigella sativa, thymoquinone, west nile virus, antiviral, anti-inflammatory, analgesic.

« Previous Next »
Graphical Abstract

[1]
Mencattelli G, Ndione MHD, Rosà R, et al. Epidemiology of West Nile virus in Africa: An underestimated threat. PLoS Negl Trop Dis 2022; 16(1): e0010075.
[http://dx.doi.org/10.1371/journal.pntd.0010075] [PMID: 35007285]
[2]
Saiz JC, Martín-Acebes MA, Blázquez AB, Escribano-Romero E, Poderoso T, de Oya N. Pathogenicity and virulence of West Nile virus revisited eight decades after its first isolation. Virulence 2021; 12(1): 1145-73.
[http://dx.doi.org/10.1080/21505594.2021.1908740] [PMID: 33843445]
[3]
Habarugira G, Suen WW, Hobson-Peters J, Hall RA, Bielefeldt-Ohmann H. West Nile virus: An update on pathobiology, epidemiology, diagnostics, control and “one health” implications. Pathogens 2020; 9(7): 589.
[http://dx.doi.org/10.3390/pathogens9070589] [PMID: 32707644]
[4]
Pervanidou D, Vakali A, Georgakopoulou T, et al. West Nile virus in humans, Greece, 2018: The largest seasonal number of cases, 9 years after its emergence in the country. Euro Surveill 2020; 25(32): 1900543.
[http://dx.doi.org/10.2807/1560-7917.ES.2020.25.32.1900543] [PMID: 32794446]
[5]
Khan SA, Chowdhury P. Global emergence of West Nile virus: Threat & preparedness in special perspective to India. Indian J Med Res 2021; 154(1): 36-50.
[http://dx.doi.org/10.4103/ijmr.IJMR_642_19] [PMID: 34782529]
[6]
Sutinen J, Fell DB, Sander B, Kulkarni MA. Comorbid conditions as risk factors for West Nile neuroinvasive disease in Ontario, Canada: A population-based cohort study. Epidemiol Infect 2022; 150: e103.
[http://dx.doi.org/10.1017/S0950268822000887] [PMID: 35543409]
[7]
Koch M, Pozsgai É, Soós V, et al. Identifying risks for severity of neurological symptoms in Hungarian West Nile virus patients. BMC Infect Dis 2021; 21(1): 65.
[http://dx.doi.org/10.1186/s12879-020-05760-7] [PMID: 33441090]
[8]
Constant O, Barthelemy J, Nagy A, Salinas S, Simonin Y. West nile virus neuroinfection in humans: Peripheral biomarkers of neuroinflammation and neuronal damage. Viruses 2022; 14(4): 756.
[http://dx.doi.org/10.3390/v14040756] [PMID: 35458486]
[9]
Lustig Y, Sofer D, Bucris ED, Mendelson E. Surveillance and diagnosis of west nile virus in the face of flavivirus cross-reactivity. Front Microbiol 2018; 9: 2421.
[http://dx.doi.org/10.3389/fmicb.2018.02421] [PMID: 30369916]
[10]
Ronca SE, Ruff JC, Murray KO. A 20-year historical review of West Nile virus since its initial emergence in North America: Has West Nile virus become a neglected tropical disease? PLoS Negl Trop Dis 2021; 15(5): e0009190.
[http://dx.doi.org/10.1371/journal.pntd.0009190] [PMID: 33956816]
[11]
Maideen NMP. Prophetic medicine-Nigella sativa (Black cumin seeds) – Potential herb for COVID-19? J Pharmacopuncture 2020; 23(2): 62-70.
[http://dx.doi.org/10.3831/KPI.2020.23.010] [PMID: 32685234]
[12]
Farag SM, Essa EE, Alharbi SA, Alfarraj S, Abu El-Hassan GMM. Agro-waste derived compounds (flax and black seed peels): Toxicological effect against the West Nile virus vector, Culex pipiens L. with special reference to GC–MS analysis. Saudi J Biol Sci 2021; 28(9): 5261-7.
[http://dx.doi.org/10.1016/j.sjbs.2021.05.038] [PMID: 34466104]
[13]
Rahman MM, Biswas S, Islam KJ, et al. Antiviral phytochemicals as potent inhibitors against NS3 protease of dengue virus. Comput Biol Med 2021; 134: 104492.
[http://dx.doi.org/10.1016/j.compbiomed.2021.104492] [PMID: 34022487]
[14]
Maideen NMP. Potential of black seeds (Nigella Sativa) in the management of COVID-19 among children. Int J Med Device Adj Treat 2021; 4: e366.
[15]
Maideen PNM, Hassan J A, Ramadan B I, Khalifa Albasti A. Potential of black seeds (nigella sativa) in the management of long COVID or post-acute sequelae of COVID-19 (PASC) and persistent COVID-19 symptoms – An insight. Infect Disord Drug Targets 2023; 23(4): e230223213955.
[http://dx.doi.org/10.2174/1871526523666230223112045]
[16]
Maideen NM. Miracle herb to cure HIV- black seeds (nigella sativa): A review. Int J Med Rev 2021; 8(3): 116-21.
[17]
Barakat EM, El Wakeel LM, Hagag RS. Effects of Nigella sativa on outcome of hepatitis C in Egypt. World J Gastroenterol 2013; 19(6): 2529-36.
[18]
Abdel-Moneim A, Morsy BM, Mahmoud AM, Abo-Seif MA, Zanaty MI. Beneficial therapeutic effects of Nigella sativa and/or Zingiber officinale in HCV patients in Egypt. EXCLI J 2013; 12: 943-55.
[PMID: 27298610]
[19]
Maiti S, Banerjee A, Nazmeen A, Kanwar M, Das S. Active-site molecular docking of nigellidine with nucleocapsid-NSP2-MPro of COVID-19 and to human IL1R–IL6R and strong antioxidant role of Nigella sativa in experimental rats. J Drug Target 2022; 30(5): 511-21.
[http://dx.doi.org/10.1080/1061186X.2020.1817040] [PMID: 32875925]
[20]
Xu H, Liu B, Xiao Z, et al. Computational and experimental studies reveal that thymoquinone blocks the entry of coronaviruses into in vitro cells. Infect Dis Ther 2021; 10(1): 483-94.
[http://dx.doi.org/10.1007/s40121-021-00400-2] [PMID: 33532909]
[21]
Umar S, Munir MT, Subhan S, et al. WITHDRAWN: Protective and antiviral activities of Nigella sativa against avian influenza (H9N2) in turkeys. J Saudi Soc Agric Sci 2016.
[http://dx.doi.org/10.1016/j.jssas.2016.09.004]
[22]
Umar S, Rehman A, Younus M, et al. Effects of Nigella sativa on immune responses and pathogenesis of avian influenza (H9N2) virus in turkeys. J Appl Poult Res 2016; 25(1): 95-103.
[http://dx.doi.org/10.3382/japr/pfv070]
[23]
Khan AU, Tipu MY, Shafee M, et al. In-ovo antiviral effect of Nigella Sativa extract against Newcastle Disease Virus in experimentally infected chicken embryonated eggs. Pak Vet J 2018; 38(4): 434-7.
[http://dx.doi.org/10.29261/pakvetj/2018.075]
[24]
Sökmen A. Antiviral and cytotoxic activities of extracts from the cell cultures and respective parts of some Turkish medicinal plants. Turk J Biol 2001; 25: 343-50.
[25]
Zihlif MA, Mahmoud IS, Ghanim MT, et al. Thymoquinone efficiently inhibits the survival of EBV-infected B cells and alters EBV gene expression. Integr Cancer Ther 2013; 12(3): 257-63.
[http://dx.doi.org/10.1177/1534735412458827] [PMID: 23089554]
[26]
Salem ML, Hossain MS. Protective effect of black seed oil from Nigella sativa against murine cytomegalovirus infection. Int J Immunopharmacol 2000; 22(9): 729-40.
[http://dx.doi.org/10.1016/S0192-0561(00)00036-9] [PMID: 10884593]
[27]
Mohamed EF. Inhibition of Broad bean mosaic virus (BBMV) using extracts of Nigella (Nigella Sativa L.) and Zizyphus (Zizyphus spina-christi Mill.) plants. J Am Sci 2011; 7(12): 727-34.
[28]
Elbeshehy EKF. Inhibitor activity of different medicinal plants extracts from Thuja orientalis, Nigella sativa L., Azadirachta indica and Bougainvillea spectabilis against Zucchini yellow mosaic virus (ZYMV) infecting Citrullus lanatus. Biotechnol Biotechnol Equip 2017; 31(2): 270-9.
[http://dx.doi.org/10.1080/13102818.2017.1279572]
[29]
Aqil K, Khan MR, Aslam A, et al. In vitro antiviral activity of nigella sativa against Peste des Petits Ruminants (PPR) Virus. Pak J Zool 2018; 50(6): 2223-8.
[http://dx.doi.org/10.17582/journal.pjz/2018.50.6.2223.2228]
[30]
Maurya S, Marimuthu P, Singh A, Rao GP, Singh G. Antiviral activity of essential oils and acetone extracts of medicinal plants against papaya ring spot virus. J Essent Oil-Bear Plants 2005; 8(3): 233-8.
[http://dx.doi.org/10.1080/0972060X.2005.10643452]
[31]
Maideen NM, Rajkapoor B, Sudha M, Mirunalini G, Mohamed R. Therapeutic potentials of black seeds (Nigella sativa) in the management of COVID-19-A review of clinical and in-silico studies. Antiinfect Agents 2022; 20: e020822207222.
[32]
Al-Ghamdi MS. The anti-inflammatory, analgesic and antipyretic activity of Nigella sativa. J Ethnopharmacol 2001; 76(1): 45-8.
[http://dx.doi.org/10.1016/S0378-8741(01)00216-1] [PMID: 11378280]
[33]
Bashir MU, Qureshi HJ. Analgesic effect of Nigella sativa seeds extract on experimentally induced pain in albino mice. J Coll Physicians Surg Pak 2010; 20(7): 464-7.
[PMID: 20642947]
[34]
Al-Naggar TB, Gómez-Serranillos MP, Carretero ME, Villar AM. Neuropharmacological activity of Nigella sativa L. extracts. J Ethnopharmacol 2003; 88(1): 63-8.
[http://dx.doi.org/10.1016/S0378-8741(03)00157-0] [PMID: 12902052]
[35]
Abdel-Fattah AFM, Matsumoto K, Watanabe H. Antinociceptive effects of Nigella sativa oil and its major component, thymoquinone, in mice. Eur J Pharmacol 2000; 400(1): 89-97.
[http://dx.doi.org/10.1016/S0014-2999(00)00340-X] [PMID: 10913589]
[36]
De Sousa DP, Nóbrega FFF, Santos CCMP, et al. Antinociceptive activity of thymoquinone and its structural analogues: A structure-activity relationship study. Trop J Pharm Res 2012; 11(4): 605-10.
[http://dx.doi.org/10.4314/tjpr.v11i4.11]
[37]
Velagapudi R, El-Bakoush A, Lepiarz I, Ogunrinade F, Olajide OA. AMPK and SIRT1 activation contribute to inhibition of neuroinflammation by thymoquinone in BV2 microglia. Mol Cell Biochem 2017; 435(1-2): 149-62.
[http://dx.doi.org/10.1007/s11010-017-3064-3] [PMID: 28551846]
[38]
Mohamed A, Shoker A, Bendjelloul F, et al. Improvement of experimental allergic encephalomyelitis (EAE) by thymoquinone; an oxidative stress inhibitor. Biomed Sci Instrum 2003; 39: 440-5.
[PMID: 12724933]
[39]
Mohamed A, Afridi DM, Garani O, Tucci M. Thymoquinone inhibits the activation of NF-kappaB in the brain and spinal cord of experimental autoimmune encephalomyelitis. Biomed Sci Instrum 2005; 41: 388-93.
[PMID: 15850137]
[40]
Fahmy HM, Noor NA, Mohammed FF, Elsayed AA, Radwan NM. Nigella sativa as an anti-inflammatory and promising remyelinating agent in the cortex and hippocampus of experimental autoimmune encephalomyelitis-induced rats. J Basic Appl Zool 2014; 67(5): 182-95.
[http://dx.doi.org/10.1016/j.jobaz.2014.08.005]
[41]
Noor NA, Fahmy HM, Mohammed FF, Elsayed AA, Radwan NM. Nigella sativa amliorates inflammation and demyelination in the experimental autoimmune encephalomyelitis-induced Wistar rats. Int J Clin Exp Pathol 2015; 8(6): 6269-86.
[PMID: 26261504]
[42]
Kooshki A, Forouzan R, Rakhshani MH, Mohammadi M. Effect of topical application of Nigella Sativa oil and oral acetaminophen on pain in elderly with knee osteoarthritis: A crossover clinical trial. Electron Physician 2016; 8(11): 3193-7.
[http://dx.doi.org/10.19082/3193] [PMID: 28344755]
[43]
Salimzadeh A, Ghourchian A, Choopani R, Hajimehdipoor H, Kamalinejad M, Abolhasani M. Effect of an orally formulated processed black cumin, from Iranian traditional medicine pharmacopoeia, in relieving symptoms of knee osteoarthritis: A prospective, randomized, double-blind and placebo-controlled clinical trial. Int J Rheum Dis 2017; 20(6): 691-701.
[http://dx.doi.org/10.1111/1756-185X.13066] [PMID: 28378356]
[44]
Azizi F, Ghorat F, Rakhshani HM, Rad M. Comparison of the effect of topical use of Nigella Sativa oil and diclofenac gel on osteoarthritis pain in older people: A randomized, double-blind, clinical trial. J Herb Med 2019; 16: 100259.
[http://dx.doi.org/10.1016/j.hermed.2019.100259]
[45]
Dolatkhah N, Amirtaheri Afshar A, Sharifi S, Rahbar M, Toopchizadeh V, Hashemian M. The effects of topical and oral Nigella sativa oil on clinical findings in knee osteoarthritis: A double-blind, randomized controlled trial. J Herb Med 2022; 33: 100562.
[http://dx.doi.org/10.1016/j.hermed.2022.100562]
[46]
Mahdy A, Gheita T. Beneficial effects of Nigella Sativa seed oil as adjunct therapy in rheumatoid arthritis. J Egypt Soc Toxicol 2009; 41: 31-7.
[47]
Gheita TA, Kenawy SA. Effectiveness of Nigella sativa oil in the management of rheumatoid arthritis patients: A placebo controlled study. Phytother Res 2012; 26(8): 1246-8.
[http://dx.doi.org/10.1002/ptr.3679] [PMID: 22162258]
[48]
Hadi V, Kheirouri S, Alizadeh M, Khabbazi A, Hosseini H. Effects of Nigella sativa oil extract on inflammatory cytokine response and oxidative stress status in patients with rheumatoid arthritis: A randomized, double-blind, placebo-controlled clinical trial. Avicenna J Phytomed 2016; 6(1): 34-43.
[PMID: 27247920]
[49]
Kheirouri S, Hadi V, Alizadeh M. Immunomodulatory effect of Nigella Sativa oil on T lymphocytes in patients with rheumatoid arthritis. Immunol Invest 2016; 45(4): 271-83.
[http://dx.doi.org/10.3109/08820139.2016.1153649] [PMID: 27100726]
[50]
Ansari MA, Ahmed SP, Haider SA, Ansari NL. Nigella Sativa: A non-conventional herbal option for the management of seasonal allergic rhinitis. Pak J Pharmacol 2006; 23(2): 31-5.
[51]
Alsamarai MA, Abdulsatar M, Alobaidi HAA. Evaluation of topical black seed oil in the treatment of allergic rhinitis. Antiinflamm Antiallergy Agents Med Chem 2014; 13(1): 75-82.
[52]
Rezaeian A, Khouzani AS. Effect of Nigella Sativa nasal spray on the treatment of chronic rhinosinusitis without a nasal polyp. Allergy Rhinol 2018; 9.
[http://dx.doi.org/10.1177/2152656718800059] [PMID: 30370173]
[53]
Nemati S, Masroorchehr M, Elahi H, Kamalinejad M, Ebrahimi SM, Akbari M. Effects of Nigella sativa extract on chronic rhinosinusitis: A randomized double blind study. Indian J Otolaryngol Head Neck Surg 2021; 73(4): 455-60.
[http://dx.doi.org/10.1007/s12070-020-02296-9] [PMID: 34722227]
[54]
Kohandel Z, Farkhondeh T, Aschner M, Samarghandian S. Anti-inflammatory effects of thymoquinone and its protective effects against several diseases. Biomed Pharmacother 2021; 138: 111492.
[http://dx.doi.org/10.1016/j.biopha.2021.111492] [PMID: 33743334]
[55]
Shad FK, Soubra W, Cordato DJ. The role of thymoquinone, a major constituent of Nigella sativa, in the treatment of inflammatory and infectious diseases. Clin Exp Pharmacol Physiol 2021; 48(11): 1445-53.
[http://dx.doi.org/10.1111/1440-1681.13553] [PMID: 34297870]
[56]
Namazi N, Mahdavi R, Alizadeh M, Farajnia S. Oxidative stress responses to Nigella Sativa oil concurrent with a low-calorie diet in obese women: A randomized, double-blind controlled clinical trial. Phytother Res 2015; 29(11): 1722-8.
[http://dx.doi.org/10.1002/ptr.5417] [PMID: 26179113]
[57]
Kaatabi H, Bamosa AO, Badar A, et al. Nigella sativa improves glycemic control and ameliorates oxidative stress in patients with type 2 diabetes mellitus: Placebo controlled participant blinded clinical trial. PLoS One 2015; 10(2): e0113486.
[http://dx.doi.org/10.1371/journal.pone.0113486] [PMID: 25706772]
[58]
Hadi S, Mirmiran P, Daryabeygi-Khotbesara R, Hadi V. Effect of Nigella Sativa oil extract on inflammatory cytokine response and oxidative stress among people with type 2 diabetes mellitus: A randomized, double-blind, placebo-controlled trial. Prog Nutr 2018; 20: 127-33.
[59]
Nikkhah-Bodaghi M, Darabi Z, Agah S, Hekmatdoost A. The effects of Nigella sativa on quality of life, disease activity index, and some of inflammatory and oxidative stress factors in patients with ulcerative colitis. Phytother Res 2019; 33(4): 1027-32.
[http://dx.doi.org/10.1002/ptr.6296] [PMID: 30666747]
[60]
Ardiana M, Pikir BS, Santoso A, Hermawan HO, Al-Farabi MJ. Effect of Nigella sativa supplementation on oxidative stress and antioxidant parameters: A meta-analysis of randomized controlled trials. ScientificWorldJournal 2020; 2020: 2390706.
[61]
El-Shanshory M, Hablas NM, Aboonq MS, et al. Nigella sativa improves anemia, enhances immunity and relieves iron overload-induced oxidative stress as a novel promising treatment in children having beta-thalassemia major. J Herb Med 2019; 16: 100245.
[http://dx.doi.org/10.1016/j.hermed.2018.11.001]

Rights & Permissions Print Cite
Article Metrics
22
5
Wayfinder Image
© 2024 Bentham Science Publishers | Privacy Policy