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Current Topics in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Mini-Review Article

Clinical Research Progress of BTK Inhibitors in the Treatment of Autoimmune Diseases

Author(s): Pei Lin, Dandan Zhang and Jun Lin*

Volume 23, Issue 28, 2023

Published on: 06 October, 2023

Page: [2609 - 2620] Pages: 12

DOI: 10.2174/0115680266264515230921052521

Price: $65

Abstract

Bruton tyrosine kinase (BTK) is an important protein of the tyrosine kinase family and plays a key role in signal transduction, proliferation, migration, and survival in B lymphocytes. The inhibition of BTK is a promising therapy for various autoimmune diseases (AD) involving abnormal B cell function, such as rheumatoid arthritis (RA), multiple sclerosis (MS), and systemic lupus erythematosus (SLE). This article briefly summarizes the role of BTK in the BCR signaling pathway, the development process of BTK inhibitors, and especially the latest progress of their clinical trials for the treatment of AD.

Keywords: Bruton's tyrosine kinase, Autoimmune disease, B cell receptor, Inhibitors, Rheumatoid arthritis, Multiple sclerosis, Systemic lupus erythematosus.

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