Title:The Biological Significance of AFF4: Promoting Transcription Elongation,
Osteogenic Differentiation and Tumor Progression
Volume: 27
Issue: 10
Author(s): Qian Long, Mingli Xiang, Linlin Xiao, Jiajia Wang, Xiaoyan Guan*, Jianguo Liu*Chengcheng Liao*
Affiliation:
- Department of Orthodontics II, Affiliated Stomatological Hospital of Zunyi Medical University, Zunyi, 563000, China
- Oral Disease Research Key Laboratory of Guizhou Tertiary Institution, School of Stomatology, Zunyi Medical
University, Zunyi, 563006, China
- Department of Orthodontics II, Affiliated Stomatological Hospital of Zunyi Medical University, Zunyi, 563000, China
- Oral Disease Research Key Laboratory of Guizhou Tertiary Institution, School of Stomatology, Zunyi Medical
University, Zunyi, 563006, China
- Department of Orthodontics II, Affiliated Stomatological Hospital of Zunyi Medical University, Zunyi, 563000, China
- Oral Disease Research Key Laboratory of Guizhou Tertiary Institution, School of Stomatology, Zunyi Medical
University, Zunyi, 563006, China
Keywords:
AFF4, SEC, transcription elongation, osteogenic differentiation, tumor, tumor progression.
Abstract: As a member of the AF4/FMR2 (AFF) family, AFF4 is a scaffold protein in the superelongation
complex (SEC). In this mini-view, we discuss the role of AFF4 as a transcription
elongation factor that mediates HIV activation and replication and stem cell osteogenic differentiation.
AFF4 also promotes the progression of head and neck squamous cell carcinoma, leukemia,
breast cancer, bladder cancer and other malignant tumors. The biological function of AFF4
is largely achieved through SEC assembly, regulates SRY-box transcription factor 2 (SOX2),
MYC, estrogen receptor alpha (ESR1), inhibitor of differentiation 1 (ID1), c-Jun and noncanonical
nuclear factor-κB (NF-κB) transcription and combines with fusion in sarcoma (FUS), unique
regulatory cyclins (CycT1), or mixed lineage leukemia (MLL). We explore the prospects of
using AFF4 as a therapeutic in Acquired immunodeficiency syndrome (AIDS) and malignant
tumors and its potential as a stemness regulator.